TXA2_STEGR
ID TXA2_STEGR Reviewed; 97 AA.
AC V9QFH8; V9QEK0;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Alpha-latrotoxin associated low molecular weight protein 2 {ECO:0000250|UniProtKB:Q4U4N3};
DE Short=Alpha-latrotoxin-associated LMWP2 {ECO:0000250|UniProtKB:Q4U4N3};
DE AltName: Full=Latrodectin-2 {ECO:0000250|UniProtKB:Q4U4N3};
DE Flags: Precursor;
OS Steatoda grossa (False black widow).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Araneoidea; Theridiidae; Steatoda.
OX NCBI_TaxID=256750;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=24316130; DOI=10.1016/j.gene.2013.11.054;
RA McCowan C., Garb J.E.;
RT "Recruitment and diversification of an ecdysozoan family of neuropeptide
RT hormones for black widow spider venom expression.";
RL Gene 536:366-375(2014).
CC -!- FUNCTION: May increase the toxicity of alpha-latrotoxin and/or other
CC venom components. Is non-toxic to mice and to the cockroach Periplaneta
CC americana. {ECO:0000250|UniProtKB:Q4U4N3}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q4U4N3}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- MISCELLANEOUS: Co-purifies with latroinsectotoxin.
CC {ECO:0000250|UniProtKB:Q4U4N3}.
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305|PubMed:24316130}.
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DR EMBL; KF751523; AHC13268.1; -; mRNA.
DR EMBL; KF751524; AHC13269.1; -; mRNA.
DR AlphaFoldDB; V9QFH8; -.
DR SMR; V9QFH8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR018251; Crust_neurhormone_CS.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR SUPFAM; SSF81778; SSF81778; 1.
DR PROSITE; PS01250; CHH_MIH_GIH; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..97
FT /note="Alpha-latrotoxin associated low molecular weight
FT protein 2"
FT /id="PRO_0000432882"
FT DISULFID 36..72
FT /evidence="ECO:0000250|UniProtKB:P55847"
FT DISULFID 52..68
FT /evidence="ECO:0000250|UniProtKB:P55847"
FT DISULFID 55..81
FT /evidence="ECO:0000250|UniProtKB:P55847"
FT CONFLICT 28
FT /note="I -> M (in Ref. 1; AHC13269)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="A -> T (in Ref. 1; AHC13269)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 97 AA; 11284 MW; 6144707392908083 CRC64;
MFKLICIVFI ATILSITSAA DNEDELTIED FLSYECNESM DIEELKEKDK VCSRCANLHK
TQSVIERCRL NCFTSEYFKN CEDNLQAKEE EPEEETL