ID   TXAC_STEGR              Reviewed;          91 AA.
AC   V9QFG9; V9QEJ6; V9QER8; V9QF75;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Alpha-latrotoxin associated low molecular weight protein SGV150-311 {ECO:0000303|PubMed:24316130};
DE            Short=Alpha-latrotoxin-associated LMWP SGV150-311 {ECO:0000303|PubMed:24316130};
DE   AltName: Full=Latrodectin {ECO:0000303|PubMed:24316130};
DE   Flags: Precursor;
OS   Steatoda grossa (False black widow).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Araneoidea; Theridiidae; Steatoda.
OX   NCBI_TaxID=256750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24316130; DOI=10.1016/j.gene.2013.11.054;
RA   McCowan C., Garb J.E.;
RT   "Recruitment and diversification of an ecdysozoan family of neuropeptide
RT   hormones for black widow spider venom expression.";
RL   Gene 536:366-375(2014).
CC   -!- FUNCTION: May increase the toxicity of alpha-latrotoxin and/or other
CC       venom components. Is non-toxic to mice and to the cockroach Periplaneta
CC       americana. {ECO:0000250|UniProtKB:P49125}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P49125}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
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DR   EMBL; KF751518; AHC13263.1; -; mRNA.
DR   EMBL; KF751519; AHC13264.1; -; mRNA.
DR   EMBL; KF751520; AHC13265.1; -; mRNA.
DR   EMBL; KF751521; AHC13266.1; -; mRNA.
DR   EMBL; KF751522; AHC13267.1; -; mRNA.
DR   AlphaFoldDB; V9QFG9; -.
DR   SMR; V9QFG9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   SUPFAM; SSF81778; SSF81778; 1.
PE   3: Inferred from homology;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..91
FT                   /note="Alpha-latrotoxin associated low molecular weight
FT                   protein SGV150-311"
FT                   /id="PRO_0000432883"
FT   CONFLICT        28
FT                   /note="D -> G (in Ref. 1; AHC13263/AHC13264)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        38
FT                   /note="N -> K (in Ref. 1; AHC13266)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        76
FT                   /note="S -> A (in Ref. 1; AHC13267)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   91 AA;  10384 MW;  F7F4DB3EAFC08263 CRC64;
     MNVLHFLILL MSVVSVFCIN PEDIGCDDSI TPEKFAENDA KCVQCKEQFE ETNMLEQCRE
     DCFKGKFFRS CVDHLSGAYD EKDDVEAPPP E