ID   TXAD_STEGR              Reviewed;          89 AA.
AC   V9QER4; V9QF72;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Alpha-latrotoxin associated low molecular weight protein SGV242-280 {ECO:0000303|PubMed:24316130};
DE            Short=Alpha-latrotoxin-associated LMWP SGV242-280 {ECO:0000303|PubMed:24316130};
DE   AltName: Full=Latrodectin {ECO:0000303|PubMed:24316130};
DE   Flags: Precursor;
OS   Steatoda grossa (False black widow).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Araneoidea; Theridiidae; Steatoda.
OX   NCBI_TaxID=256750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24316130; DOI=10.1016/j.gene.2013.11.054;
RA   McCowan C., Garb J.E.;
RT   "Recruitment and diversification of an ecdysozoan family of neuropeptide
RT   hormones for black widow spider venom expression.";
RL   Gene 536:366-375(2014).
CC   -!- FUNCTION: May increase the toxicity of alpha-latrotoxin and/or other
CC       venom components. Is non-toxic to mice and to the cockroach Periplaneta
CC       americana. {ECO:0000250|UniProtKB:P49125}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P49125}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
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DR   EMBL; KF751516; AHC13261.1; -; mRNA.
DR   EMBL; KF751517; AHC13262.1; -; mRNA.
DR   AlphaFoldDB; V9QER4; -.
DR   SMR; V9QER4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   SUPFAM; SSF81778; SSF81778; 1.
PE   3: Inferred from homology;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..89
FT                   /note="Alpha-latrotoxin associated low molecular weight
FT                   protein SGV242-280"
FT                   /id="PRO_0000432884"
FT   CONFLICT        9
FT                   /note="L -> I (in Ref. 1; AHC13262)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        40
FT                   /note="T -> A (in Ref. 1; AHC13262)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   89 AA;  10044 MW;  D66AC93FEB25FC0D CRC64;
     MSKLHFLILL SVIVSVFCIE PQDIGCTGIS TAEFEEKDAT CSKCEEDYSG NGMIDRCRSD
     CYSGPFFKSC VELLNKGYDE KDENVKPEW