TXAG5_AGEOR
ID TXAG5_AGEOR Reviewed; 69 AA.
AC Q5Y4W1;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=U5-agatoxin-Ao1a;
DE Short=U5-AGTX-Ao1a;
DE AltName: Full=AgorTX_A3;
DE Flags: Precursor;
OS Agelena orientalis (Funnel-web spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Agelenidae; Agelena.
OX NCBI_TaxID=293813;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=15688451; DOI=10.1002/prot.20390;
RA Kozlov S.A., Malyavka A., McCutchen B., Lu A., Schepers E., Herrmann R.,
RA Grishin E.V.;
RT "A novel strategy for the identification of toxinlike structures in spider
RT venom.";
RL Proteins 59:131-140(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- PTM: Does not contain a cysteine at position 61 which disrupts the
CC cysteine framework.
CC -!- SIMILARITY: Belongs to the neurotoxin 01 (U2-agtx) family.
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DR EMBL; AY681323; AAU93679.1; -; mRNA.
DR AlphaFoldDB; Q5Y4W1; -.
DR SMR; Q5Y4W1; -.
DR ArachnoServer; AS000089; U5-agatoxin-Ao1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Amidation; Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..34
FT /evidence="ECO:0000250"
FT /id="PRO_5000093649"
FT CHAIN 35..69
FT /note="U5-agatoxin-Ao1a"
FT /id="PRO_5000093650"
FT DISULFID 36..52
FT /evidence="ECO:0000250"
FT DISULFID 43..57
FT /evidence="ECO:0000250"
SQ SEQUENCE 69 AA; 7559 MW; 0910E2810CEC5583 CRC64;
MRTIISLLLL SAMVFAVIEA ISLEEGLQLF EGERGCVGEN QQCADWAGPH CCSGLRCKEL
SIWDSRCLG