ID   TXAG6_AGEOR             Reviewed;          74 AA.
AC   Q5Y4W0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=U6-agatoxin-Ao1a;
DE            Short=U6-AGTX-Ao1a;
DE   AltName: Full=AgorTX_A4;
DE   Flags: Precursor;
OS   Agelena orientalis (Funnel-web spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Agelenidae; Agelena.
OX   NCBI_TaxID=293813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=15688451; DOI=10.1002/prot.20390;
RA   Kozlov S.A., Malyavka A., McCutchen B., Lu A., Schepers E., Herrmann R.,
RA   Grishin E.V.;
RT   "A novel strategy for the identification of toxinlike structures in spider
RT   venom.";
RL   Proteins 59:131-140(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
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DR   EMBL; AY681324; AAU93680.1; -; mRNA.
DR   AlphaFoldDB; Q5Y4W0; -.
DR   ArachnoServer; AS000088; U6-agatoxin-Ao1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..30
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5000093651"
FT   CHAIN           31..74
FT                   /note="U6-agatoxin-Ao1a"
FT                   /id="PRO_5000093652"
FT   DISULFID        44..56
FT                   /evidence="ECO:0000305"
FT   DISULFID        49..61
FT                   /evidence="ECO:0000305"
FT   DISULFID        55..72
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   74 AA;  8405 MW;  8F5D76963477C862 CRC64;
     MRFYIAFFFL LLAADMALSF EIGNSEELER LSMVYGEVES ERGCTHGSCE NGETCCDGWR
     CRYTGRAVPF MCVP