ID   TXAG9_AGEOR             Reviewed;         110 AA.
AC   Q5Y4U3;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=U9-agatoxin-Ao1a;
DE            Short=U9-AGTX-Ao1a;
DE   AltName: Full=AgorTX_B7a;
DE   Flags: Precursor;
OS   Agelena orientalis (Funnel-web spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Agelenidae; Agelena.
OX   NCBI_TaxID=293813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=15688451; DOI=10.1002/prot.20390;
RA   Kozlov S.A., Malyavka A., McCutchen B., Lu A., Schepers E., Herrmann R.,
RA   Grishin E.V.;
RT   "A novel strategy for the identification of toxinlike structures in spider
RT   venom.";
RL   Proteins 59:131-140(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 37 family.
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DR   EMBL; AY681342; AAU93683.1; -; mRNA.
DR   AlphaFoldDB; Q5Y4U3; -.
DR   ArachnoServer; AS000071; U9-agatoxin-Ao1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013605; Toxin_34.
DR   Pfam; PF08396; Toxin_34; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..38
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5000093685"
FT   CHAIN           39..108
FT                   /note="U9-agatoxin-Ao1a"
FT                   /id="PRO_5000093686"
FT   DISULFID        40..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   110 AA;  11866 MW;  F4F99893B296AB71 CRC64;
     MKLLLAIAGL FLVQTLAEDV RAHEESSFLA AVAPEEQRAC IKEGEKCAGD CQCCGKWSYC
     SCPLFGALGC SCIIGDAMVC VRKKKECRTS DVMNTPPGGC FSSSKRRHGR