ID   TXA_ANDCR               Reviewed;          28 AA.
AC   P0C2A1;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Toxin a {ECO:0000305};
DE   AltName: Full=Subcomponent a {ECO:0000303|PubMed:16762386};
DE   Flags: Fragment;
OS   Androctonus crassicauda (Arabian fat-tailed scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Androctonus.
OX   NCBI_TaxID=122909;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=16762386; DOI=10.1016/j.toxicon.2006.04.003;
RA   Caliskan F., Garcia B.I., Coronas F.I.V., Batista C.V.F., Zamudio F.Z.,
RA   Possani L.D.;
RT   "Characterization of venom components from the scorpion Androctonus
RT   crassicauda of Turkey: peptides and genes.";
RL   Toxicon 48:12-22(2006).
CC   -!- FUNCTION: Binds to sodium channels (Nav) and affects the channel
CC       activation process. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16762386}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:16762386}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the long (3 C-C) scorpion toxin superfamily.
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DR   AlphaFoldDB; P0C2A1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR   PROSITE; PS51863; LCN_CSAB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>28
FT                   /note="Toxin a"
FT                   /id="PRO_0000271328"
FT   DOMAIN          3..>28
FT                   /note="LCN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   UNSURE          8
FT                   /note="P or Q"
FT   UNSURE          9
FT                   /note="L or N"
FT   UNSURE          14
FT                   /note="N or A"
FT   UNSURE          17
FT                   /note="P or G"
FT   NON_TER         28
SQ   SEQUENCE   28 AA;  3069 MW;  E1000FE55B7B6C89 CRC64;
     ADVPGNYPLD SYGNCYPCTI LGDNQYCI