ID   TXB1A_SCODE             Reviewed;         219 AA.
AC   P0DQA3;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Kappa-scoloptoxin(11)-Ss1a {ECO:0000305};
DE            Short=Kappa-SLPTX(11)-Ss1a {ECO:0000305};
DE   AltName: Full=Toxin SSD92 {ECO:0000303|PubMed:23148443};
DE   Flags: Precursor;
OS   Scolopendra dehaani (Thai centipede) (Scolopendra subspinipes dehaani).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2609776;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-47, SUBCELLULAR
RP   LOCATION, MASS SPECTROMETRY, AND FUNCTION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=23148443; DOI=10.1021/pr300881d;
RA   Liu Z.C., Zhang R., Zhao F., Chen Z.M., Liu H.W., Wang Y.J., Jiang P.,
RA   Zhang Y., Wu Y., Ding J.P., Lee W.H., Zhang Y.;
RT   "Venomic and transcriptomic analysis of centipede Scolopendra subspinipes
RT   dehaani.";
RL   J. Proteome Res. 11:6197-6212(2012).
CC   -!- FUNCTION: Voltage-gated potassium channel inhibitor.
CC       {ECO:0000305|PubMed:23148443}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23148443}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:23148443}.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=22462.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:23148443};
CC   -!- SIMILARITY: Belongs to the scoloptoxin-11 family. {ECO:0000305}.
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DR   EMBL; KC144104; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0DQA3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..25
FT                   /evidence="ECO:0000305|PubMed:23148443"
FT                   /id="PRO_0000446762"
FT   CHAIN           26..219
FT                   /note="Kappa-scoloptoxin(11)-Ss1a"
FT                   /evidence="ECO:0000305|PubMed:23148443"
FT                   /id="PRO_0000446763"
SQ   SEQUENCE   219 AA;  25497 MW;  B87DA02FCD192B3B CRC64;
     MFYSHLLFFT FTFACSSSLN RKTKREMDLE DIILDTCHQK AVCAHIQMHL KETYVDELCK
     CGGGQECPLH WDPNDGHSIT LAYNQWKFCS PTSQDLPVCT REQTAREFSY DMKPVSKKVQ
     MFMFFNCLCP ENHFYEFFNE REEETGGGQL AIIEERCEKM KQCEKTQICQ KIETLQGKFL
     FKHVKCFCPG DQNCNDDLKK ADAIDVGDDG SVQHYMKCH