TXB1B_DANRE
ID TXB1B_DANRE Reviewed; 823 AA.
AC Q6P132; Q6P958;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 3.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Tax1-binding protein 1 homolog B;
GN Name=tax1bp1b; Synonyms=tax1bp1; ORFNames=zgc:77129;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Retina;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=18638469; DOI=10.1016/j.ydbio.2008.06.032;
RA Ahn D., Ho R.K.;
RT "Tri-phasic expression of posterior Hox genes during development of
RT pectoral fins in zebrafish: implications for the evolution of vertebrate
RT paired appendages.";
RL Dev. Biol. 322:220-233(2008).
CC -!- FUNCTION: May have anti-apoptotic activity. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P132-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P132-2; Sequence=VSP_037667;
CC -!- TISSUE SPECIFICITY: Expressed at relatively high levels in both
CC proximal and distal regions of the fin bud during pectoral fin
CC development. {ECO:0000269|PubMed:18638469}.
CC -!- DOMAIN: The C-terminal UBZ-type zinc fingers function as ubiquitin-
CC binding domains. {ECO:0000250|UniProtKB:Q86VP1}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH60918.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH65315.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC060918; AAH60918.1; ALT_INIT; mRNA.
DR EMBL; BC065315; AAH65315.1; ALT_INIT; mRNA.
DR RefSeq; NP_997829.1; NM_212664.1.
DR RefSeq; XP_005158013.1; XM_005157956.2. [Q6P132-2]
DR AlphaFoldDB; Q6P132; -.
DR SMR; Q6P132; -.
DR STRING; 7955.ENSDARP00000040726; -.
DR PaxDb; Q6P132; -.
DR PRIDE; Q6P132; -.
DR Ensembl; ENSDART00000169541; ENSDARP00000137903; ENSDARG00000056856. [Q6P132-2]
DR GeneID; 324152; -.
DR KEGG; dre:324152; -.
DR CTD; 324152; -.
DR ZFIN; ZDB-GENE-030131-2872; tax1bp1b.
DR eggNOG; ENOG502QQ1D; Eukaryota.
DR GeneTree; ENSGT00950000183025; -.
DR InParanoid; Q6P132; -.
DR OrthoDB; 179838at2759; -.
DR PhylomeDB; Q6P132; -.
DR TreeFam; TF329501; -.
DR Reactome; R-DRE-5357905; Regulation of TNFR1 signaling.
DR Reactome; R-DRE-936440; Negative regulators of DDX58/IFIH1 signaling.
DR PRO; PR:Q6P132; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000056856; Expressed in caudal fin and 28 other tissues.
DR ExpressionAtlas; Q6P132; baseline.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR InterPro; IPR012852; CALCOCO1-like.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR Pfam; PF07888; CALCOCO1; 1.
DR Pfam; PF17751; SKICH; 1.
DR Pfam; PF18112; Zn-C2H2_12; 2.
DR PROSITE; PS51905; ZF_UBZ1; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Apoptosis; Coiled coil; Metal-binding;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..823
FT /note="Tax1-binding protein 1 homolog B"
FT /id="PRO_0000234558"
FT ZN_FING 762..788
FT /note="UBZ1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT ZN_FING 789..815
FT /note="UBZ1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT REGION 342..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..487
FT /evidence="ECO:0000255"
FT COILED 548..638
FT /evidence="ECO:0000255"
FT BINDING 765
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT BINDING 768
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT BINDING 784
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT BINDING 788
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT BINDING 792
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT BINDING 795
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT BINDING 811
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT BINDING 815
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT VAR_SEQ 623
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_037667"
FT CONFLICT 139
FT /note="E -> D (in Ref. 1; AAH65315)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="R -> K (in Ref. 1; AAH65315)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="Q -> H (in Ref. 1; AAH65315)"
FT /evidence="ECO:0000305"
FT CONFLICT 485
FT /note="N -> S (in Ref. 1; AAH65315)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 823 AA; 94511 MW; 7A0F5442E4C36C25 CRC64;
MALFLEGTAA SSAMETSNFA HVIFQNVGKS YLPHGALECH YTLTQFIKPH PKDWVGIFKV
GWSTARDYYT FLWSPLPDNY TEGTAINRSV VFQGYYVPND DGEFYQFCYV THKGEIRGAS
TPFQFRANSP TEEELLTMED EGGSDILVVT TKASYLEQKM EQIQQEKKEL LENLDLLQKE
RDELIDEKNR LEKEYEQERE SSAQLRKDVQ ELQLSAQSLQ EEREEVKRRM EESTARLLQL
EEDLIGVTQK GLQKETELDC LKDRVKKLNL EKEALEGQLK NEKDEKELYK IHLKNRELEN
TKLSAELQML KSVDVNKENT IAQLKDELAR VKSCLAEKEK QHRQLLANSS PSGESKALRE
QLRQKEEQLQ ATQQQANMLK AELRDSSNAR DRSMAELYRI RVEAETLKKG QADARAECSR
LEQQLEEMKS STQQEAQCKE SDVLAVAELQ REVEDLRLRL QMAAEHYKDK YKECQKLQKQ
VVKFNEQQGV KRSPGSDAAA GPLSASPEAS APGSPSTSDA VLDAIIHGRL KSSSKELDKN
DKYRKCKQML NEERERCSMI TDELTKMEVK LREQMKTNES LRMQLAAEED RYKSQVAEKG
RELKELKDSL FVLTKEKEKL EGQLQKSVNR EEEQKDSNLD VQSVFLQYPM PYAQDDPSPL
LVPQRPTDLL FGNPYSSTDS RDGADGEFSD DQMPRLPPVG PPSWDSNVVC IQPARNLSRP
DGLEEPEEPQ STQNDDEPAA PEPAEFLNDG QMPFCFEPTG EQKRCPLCEV IFPPHYDQSK
FEEHVESHWK ICPMCSEQFP LDCDQQLFEK HVLTHFDSNV LNF
