TXB3A_SCODE
ID TXB3A_SCODE Reviewed; 227 AA.
AC P0DQA5;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 25-MAY-2022, entry version 6.
DE RecName: Full=U-scoloptoxin(11)-Ssd3a {ECO:0000305};
DE Short=U-SLPTX(11)-Ssd3a {ECO:0000305};
DE AltName: Full=Toxin SSD431 {ECO:0000303|PubMed:23148443};
DE Flags: Precursor;
OS Scolopendra dehaani (Thai centipede) (Scolopendra subspinipes dehaani).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX NCBI_TaxID=2609776;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 31-50, SUBCELLULAR
RP LOCATION, MASS SPECTROMETRY, AND FUNCTION.
RC TISSUE=Venom, and Venom gland;
RX PubMed=23148443; DOI=10.1021/pr300881d;
RA Liu Z.C., Zhang R., Zhao F., Chen Z.M., Liu H.W., Wang Y.J., Jiang P.,
RA Zhang Y., Wu Y., Ding J.P., Lee W.H., Zhang Y.;
RT "Venomic and transcriptomic analysis of centipede Scolopendra subspinipes
RT dehaani.";
RL J. Proteome Res. 11:6197-6212(2012).
CC -!- FUNCTION: Anticoagulant toxin. {ECO:0000269|PubMed:23148443}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23148443}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:23148443}.
CC -!- PTM: Contains 8 disulfide bonds. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=22213.7; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:23148443};
CC -!- SIMILARITY: Belongs to the scoloptoxin-11 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KC144430; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0DQA5; -.
DR SMR; P0DQA5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Blood coagulation cascade inhibiting toxin;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Hemostasis impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..14
FT /evidence="ECO:0000255"
FT PROPEP 15..30
FT /evidence="ECO:0000305|PubMed:23148443"
FT /id="PRO_0000446772"
FT CHAIN 31..227
FT /note="U-scoloptoxin(11)-Ssd3a"
FT /evidence="ECO:0000305|PubMed:23148443"
FT /id="PRO_0000446773"
SQ SEQUENCE 227 AA; 25841 MW; 5C003C7901BD0A71 CRC64;
MYLLFGFIFL AAEAFNLRNV MESKELFKKR ELTTEDELAT CNSDSICGYL QNNVKGTNYV
PLCACPGEIR CPHSWDSNDG KSLTRGNEQF KFCSSSPQDL HDCKANELVF TAVYEYLSNV
NPKKFAAYIG NIHCKCPDEF AYNLFNRTKK ATADREIQTV YFSCQEYNIC GSNDTCHIIS
ESPDNFHIYK ICNCDNGLQC SDNPDAAFKT VKLEQGPLFN QYSMRCQ