ID   TXB3A_SCOMU             Reviewed;          84 AA.
AC   I6S7G5;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Kappa-scoloptoxin(11)-Ssm3a {ECO:0000303|PubMed:24847043};
DE            Short=Kappa-SLPTX(11)-Ssm3a {ECO:0000303|PubMed:24847043};
DE   AltName: Full=Kappa-scoloptoxin-Ssm3a {ECO:0000303|PubMed:22595790};
DE            Short=Kappa-SLPTX-Ssm3a {ECO:0000303|PubMed:22595790};
DE   Flags: Precursor;
OS   Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS   subspinipes mutilans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2836329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-84, FUNCTION, BIOASSAY,
RP   TOXIC DOSE, DISULFIDE BONDS, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=22595790; DOI=10.1074/mcp.m112.018853;
RA   Yang S., Liu Z., Xiao Y., Li Y., Rong M., Liang S., Zhang Z., Yu H.,
RA   King G.F., Lai R.;
RT   "Chemical punch packed in venoms makes centipedes excellent predators.";
RL   Mol. Cell. Proteomics 11:640-650(2012).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24847043; DOI=10.1093/molbev/msu162;
RA   Undheim E.A., Jones A., Clauser K.R., Holland J.W., Pineda S.S., King G.F.,
RA   Fry B.G.;
RT   "Clawing through evolution: toxin diversification and convergence in the
RT   ancient lineage Chilopoda (centipedes).";
RL   Mol. Biol. Evol. 31:2124-2148(2014).
CC   -!- FUNCTION: Inhibits voltage-gated potassium channel currents in DRG
CC       neurons. 200 nM of the toxin inhibits current amplitude by only 25% and
CC       even at concentrations up to 5 uM, the toxin does not inhibit all
CC       potassium currents. In vivo, insects injected with this toxin showed
CC       signs of neurotoxicity including twitching, paralysis, and body
CC       contraction. {ECO:0000269|PubMed:22595790}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22595790}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:22595790}.
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=7989.05; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22595790};
CC   -!- TOXIC DOSE: the LD(50) ranges from 0.040 mg/kg in adult blowflies to
CC       24.1 mg/kg in mealworms. {ECO:0000269|PubMed:22595790}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-11 family. {ECO:0000305}.
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DR   EMBL; JN646116; AFM55005.1; -; mRNA.
DR   AlphaFoldDB; I6S7G5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000269|PubMed:22595790"
FT   CHAIN           17..84
FT                   /note="Kappa-scoloptoxin(11)-Ssm3a"
FT                   /evidence="ECO:0000269|PubMed:22595790"
FT                   /id="PRO_0000425485"
SQ   SEQUENCE   84 AA;  9869 MW;  33B2343F4CC31FD4 CRC64;
     MSWMFYSFIV FTLAIKEVIA IDGLEICSND QLHVTIYSIF SPLFDKPKLN YYFNCSCPGS
     IYISDVYPKY FNDIAHIEYR CKLT