TXC16_CUPSA
ID TXC16_CUPSA Reviewed; 38 AA.
AC B3EWS9;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Toxin CSTX-16 {ECO:0000303|PubMed:22672445};
DE Contains:
DE RecName: Full=CSTX-16 A chain {ECO:0000303|PubMed:22672445};
DE Contains:
DE RecName: Full=CSTX-16 B chain {ECO:0000303|PubMed:22672445};
DE Flags: Precursor; Fragments;
OS Cupiennius salei (American wandering spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Cupiennius.
OX NCBI_TaxID=6928;
RN [1]
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND AMIDATION AT GLN-19 AND GLN-38.
RC TISSUE=Venom;
RX PubMed=22672445; DOI=10.1111/j.1742-4658.2012.08650.x;
RA Trachsel C., Siegemund D., Kampfer U., Kopp L.S., Buhr C., Grossmann J.,
RA Luthi C., Cunningham M., Nentwig W., Kuhn-Nentwig L., Schurch S.,
RA Schaller J.;
RT "Multicomponent venom of the spider Cupiennius salei: a bioanalytical
RT investigation applying different strategies.";
RL FEBS J. 279:2683-2694(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22672445}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:22672445}.
CC -!- MASS SPECTROMETRY: [CSTX-16 A chain]: Mass=2370.371;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:22672445};
CC -!- MASS SPECTROMETRY: [CSTX-16 B chain]: Mass=2504.347;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:22672445};
CC -!- SIMILARITY: Belongs to the cationic peptide 04 (cupiennin) family. 10
CC (double chain) subfamily.
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DR AlphaFoldDB; B3EWS9; -.
DR SMR; B3EWS9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Secreted; Toxin.
FT PEPTIDE 1..19
FT /note="CSTX-16 A chain"
FT /evidence="ECO:0000269|PubMed:22672445"
FT /id="PRO_0000421187"
FT PEPTIDE 20..38
FT /note="CSTX-16 B chain"
FT /evidence="ECO:0000269|PubMed:22672445"
FT /id="PRO_0000421188"
FT MOD_RES 19
FT /note="Glutamine amide"
FT /evidence="ECO:0000269|PubMed:22672445"
FT MOD_RES 38
FT /note="Glutamine amide"
FT /evidence="ECO:0000269|PubMed:22672445"
FT NON_CONS 19..20
FT /evidence="ECO:0000303|PubMed:22672445"
SQ SEQUENCE 38 AA; 4748 MW; B9EF8877B3B095E8 CRC64;
NFLEMLKENC KLLWKRQKQK FRIPMPESLC QILKKKKQ