TXC4B_CUPSA
ID TXC4B_CUPSA Reviewed; 27 AA.
AC B3EWV7;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Cupiennin-4b {ECO:0000303|Ref.2};
DE Short=Cu-4b {ECO:0000303|Ref.2};
DE AltName: Full=Short cationic peptide-4b {ECO:0000303|PubMed:22672445};
DE Short=SCP-4b {ECO:0000303|PubMed:22672445};
OS Cupiennius salei (American wandering spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Cupiennius.
OX NCBI_TaxID=6928;
RN [1]
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND AMIDATION AT GLN-27.
RC TISSUE=Venom;
RX PubMed=22672445; DOI=10.1111/j.1742-4658.2012.08650.x;
RA Trachsel C., Siegemund D., Kampfer U., Kopp L.S., Buhr C., Grossmann J.,
RA Luthi C., Cunningham M., Nentwig W., Kuhn-Nentwig L., Schurch S.,
RA Schaller J.;
RT "Multicomponent venom of the spider Cupiennius salei: a bioanalytical
RT investigation applying different strategies.";
RL FEBS J. 279:2683-2694(2012).
RN [2]
RP NOMENCLATURE.
RA Kuhn-Nentwig L., Gohel T.;
RL Unpublished observations (JUN-2015).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22672445}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:22672445}.
CC -!- MASS SPECTROMETRY: Mass=3114.898; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:22672445};
CC -!- SIMILARITY: Belongs to the cationic peptide 04 (cupiennin) family. 08
CC subfamily. {ECO:0000305}.
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DR AlphaFoldDB; B3EWV7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR InterPro; IPR035164; Cupiennin.
DR Pfam; PF17563; Cu; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Secreted; Toxin.
FT PEPTIDE 1..27
FT /note="Cupiennin-4b"
FT /evidence="ECO:0000269|PubMed:22672445"
FT /id="PRO_0000421214"
FT MOD_RES 27
FT /note="Glutamine amide"
FT /evidence="ECO:0000269|PubMed:22672445"
SQ SEQUENCE 27 AA; 3118 MW; A3EADC33C7F2ED23 CRC64;
VYGMLFKFLA KKVAKKLISH VAKKQLQ