ID   TXC5_PHONI              Reviewed;          33 AA.
AC   P84015;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=U23-ctenitoxin-Pn1a {ECO:0000305};
DE            Short=U23-CNTX-Pn1a {ECO:0000305};
DE   AltName: Full=Venom protein PN10C5 {ECO:0000303|Ref.2};
OS   Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Phoneutria.
OX   NCBI_TaxID=6918;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=16278100; DOI=10.1016/j.cbpc.2005.09.010;
RA   Richardson M., Pimenta A.M., Bemquerer M.P., Santoro M.M., Beirao P.S.,
RA   Lima M.E., Figueiredo S.G., Bloch C. Jr., Vasconcelos E.A., Campos F.A.,
RA   Gomes P.C., Cordeiro M.N.;
RT   "Comparison of the partial proteomes of the venoms of Brazilian spiders of
RT   the genus Phoneutria.";
RL   Comp. Biochem. Physiol. 142:173-187(2006).
RN   [2]
RP   FUNCTION.
RA   Richardson M., Pimenta A.M.C., Bemquerer M.P., Santoro M.M.,
RA   Figueiredo S.G., Cordeiro M.N.;
RT   "New peptide PN10C5 from venom of Brazilian armed spider Phoneutria
RT   nigriventer has sequence similarities with snake disintegrins, vasotocin-
RT   neurophysins and other spider toxins.";
RL   Submitted (JUN-2004) to UniProtKB.
CC   -!- FUNCTION: Non-toxic to mice. {ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16278100}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:16278100}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P86269}.
CC   -!- MASS SPECTROMETRY: Mass=3672.7; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16278100};
CC   -!- SIMILARITY: Belongs to the neurotoxin 33 family. {ECO:0000305}.
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DR   AlphaFoldDB; P84015; -.
DR   SMR; P84015; -.
DR   ArachnoServer; AS000297; U23-ctenitoxin-Pn1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted.
FT   PEPTIDE         1..33
FT                   /note="U23-ctenitoxin-Pn1a"
FT                   /evidence="ECO:0000269|PubMed:16278100"
FT                   /id="PRO_0000044979"
FT   DISULFID        3..16
FT                   /evidence="ECO:0000250|UniProtKB:P86269"
FT   DISULFID        10..21
FT                   /evidence="ECO:0000250|UniProtKB:P86269"
FT   DISULFID        15..30
FT                   /evidence="ECO:0000250|UniProtKB:P86269"
SQ   SEQUENCE   33 AA;  3679 MW;  77F1127D4785D6E1 CRC64;
     GFCAQKGIKC HDIHCCTNLK CVREGSNRVC RKA