TXCL1_CALPA
ID TXCL1_CALPA Reviewed; 79 AA.
AC P14531;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Delta-hormotoxin-Cpt1b {ECO:0000303|PubMed:22683676};
DE Short=Delta-HRTX-Cpt1b {ECO:0000303|PubMed:22683676};
DE AltName: Full=Calitoxin {ECO:0000303|PubMed:2567180};
DE Short=CLX {ECO:0000303|PubMed:2567180};
DE AltName: Full=Calitoxin-1 {ECO:0000303|PubMed:7510258};
DE Short=CLX-1 {ECO:0000303|PubMed:7510258};
DE AltName: Full=Neurotoxic peptide;
DE Flags: Precursor;
OS Calliactis parasitica (Sea anemone) (Actinia parasitica).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Nynantheae; Hormathiidae; Calliactis.
OX NCBI_TaxID=6114;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7510258; DOI=10.1016/0378-1119(94)90805-2;
RA Spagnuolo A., Zanetti L., Cariello L., Piccoli R.;
RT "Isolation and characterization of two genes encoding calitoxins,
RT neurotoxic peptides from Calliactis parasitica (Cnidaria).";
RL Gene 138:187-191(1994).
RN [2]
RP PROTEIN SEQUENCE OF 34-79, AND FUNCTION.
RX PubMed=2567180; DOI=10.1021/bi00432a020;
RA Cariello L., de Santis A., Fiore F., Piccoli R., Spagnuolo A., Zanetti L.,
RA Parente A.;
RT "Calitoxin, a neurotoxic peptide from the sea anemone Calliactis
RT parasitica: amino acid sequence and electrophysiological properties.";
RL Biochemistry 28:2484-2489(1989).
RN [3]
RP NOMENCLATURE.
RX PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA Oliveira J.S., Fuentes-Silva D., King G.F.;
RT "Development of a rational nomenclature for naming peptide and protein
RT toxins from sea anemones.";
RL Toxicon 60:539-550(2012).
CC -!- FUNCTION: In neuromuscular preparation of crustaceans, the toxin
CC increased neurotransmitter release, causing repetitive firing of the
CC axons. May affect sodium channels (Nav). {ECO:0000269|PubMed:2567180,
CC ECO:0000269|PubMed:7510258}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC family. {ECO:0000305}.
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DR EMBL; S69403; AAB30193.1; -; Genomic_DNA.
DR PIR; A31863; A31863.
DR AlphaFoldDB; P14531; -.
DR SMR; P14531; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 2.20.20.10; -; 1.
DR InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Ion channel impairing toxin; Nematocyst; Neurotoxin;
KW Secreted; Signal; Toxin; Voltage-gated sodium channel impairing toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..31
FT /evidence="ECO:0000269|PubMed:2567180"
FT /id="PRO_0000034863"
FT CHAIN 34..79
FT /note="Delta-hormotoxin-Cpt1b"
FT /evidence="ECO:0000269|PubMed:2567180"
FT /id="PRO_0000034864"
FT DISULFID 36..75
FT /evidence="ECO:0000250"
FT DISULFID 38..66
FT /evidence="ECO:0000250"
FT DISULFID 56..76
FT /evidence="ECO:0000250"
FT CONFLICT 78
FT /note="Q -> E (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 79 AA; 8728 MW; A4EB716B9B6F3FA7 CRC64;
MKTQVLALFV LCVLFCLAES RTTLNKRNDI EKRIECKCEG DAPDLSHMTG TVYFSCKGGD
GSWSKCNTYT AVADCCHQA
