ID   TXCL2_CALPA             Reviewed;          79 AA.
AC   P49127;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Delta-hormotoxin-Cpt1a {ECO:0000303|PubMed:22683676};
DE            Short=Delta-HRTX-Cpt1a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Calitoxin-2 {ECO:0000303|PubMed:7510258};
DE            Short=CLX-2 {ECO:0000303|PubMed:7510258};
DE   Flags: Precursor;
OS   Calliactis parasitica (Sea anemone) (Actinia parasitica).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Nynantheae; Hormathiidae; Calliactis.
OX   NCBI_TaxID=6114;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7510258; DOI=10.1016/0378-1119(94)90805-2;
RA   Spagnuolo A., Zanetti L., Cariello L., Piccoli R.;
RT   "Isolation and characterization of two genes encoding calitoxins,
RT   neurotoxic peptides from Calliactis parasitica (Cnidaria).";
RL   Gene 138:187-191(1994).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: In neuromuscular preparation of crustaceans, the toxin
CC       increased neurotransmitter release, causing repetitive firing of the
CC       axons. May affect sodium channels (Nav).
CC       {ECO:0000250|UniProtKB:P14531}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. {ECO:0000305}.
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DR   EMBL; S69399; AAD14039.1; -; Genomic_DNA.
DR   AlphaFoldDB; P49127; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Nematocyst; Neurotoxin; Secreted; Signal;
KW   Toxin; Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..31
FT                   /evidence="ECO:0000250|UniProtKB:P14531"
FT                   /id="PRO_0000034865"
FT   CHAIN           34..79
FT                   /note="Delta-hormotoxin-Cpt1a"
FT                   /id="PRO_0000034866"
FT   DISULFID        36..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..76
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8654 MW;  306FB6E7F96F3AE2 CRC64;
     MKTQVLAVFV LCVLFCLAES RTTLNKRIDI AKRIECKCKG DAPDLSHMTG TVYFSCKGGD
     GSWSKCNTYT AVADCCHQA