TXD06_LYCSI
ID TXD06_LYCSI Reviewed; 120 AA.
AC B6DD24;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 20.
DE RecName: Full=U13-lycotoxin-Ls1e;
DE AltName: Full=Toxin-like structure LSTX-L6;
DE Flags: Precursor;
OS Lycosa singoriensis (Wolf spider) (Aranea singoriensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Lycosa.
OX NCBI_TaxID=434756;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=19875276; DOI=10.1016/j.zool.2009.04.001;
RA Zhang Y., Chen J., Tang X., Wang F., Jiang L., Xiong X., Wang M., Rong M.,
RA Liu Z., Liang S.;
RT "Transcriptome analysis of the venom glands of the Chinese wolf spider
RT Lycosa singoriensis.";
RL Zoology 113:10-18(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide kOR'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- PTM: Contains 6 disulfide bonds. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the neurotoxin 05 (agouti) family.
CC {ECO:0000305}.
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DR EMBL; EU926108; ACI41440.1; -; mRNA.
DR EMBL; FM864112; CAS03709.1; -; mRNA.
DR AlphaFoldDB; B6DD24; -.
DR ArachnoServer; AS001047; U13-lycotoxin-Ls1e.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT PROPEP 17..54
FT /evidence="ECO:0000250"
FT /id="PRO_0000401867"
FT CHAIN 55..120
FT /note="U13-lycotoxin-Ls1e"
FT /id="PRO_0000401868"
FT DOMAIN 56..95
FT /note="Agouti"
FT DISULFID 56..70
FT /evidence="ECO:0000250"
FT DISULFID 63..76
FT /evidence="ECO:0000250"
FT DISULFID 69..87
FT /evidence="ECO:0000250"
FT DISULFID 78..85
FT /evidence="ECO:0000250"
SQ SEQUENCE 120 AA; 13745 MW; C77615E8C4C05551 CRC64;
MKILFVLISI LYAVYCFSSE EDVDSAYLAN ELEPVEDINS EQYAALEPKE EQERSCAGMG
RDCKDDCDCC LNIATCNCWF GRYFCSCTFG DYQTCLRKKG KCKRNRPQSC PRSNLNRKKG