TXD15_MOUSE
ID TXD15_MOUSE Reviewed; 344 AA.
AC Q6P6J9; Q52KM6; Q8BV80; Q8K319;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Thioredoxin domain-containing protein 15;
DE Flags: Precursor;
GN Name=Txndc15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J; TISSUE=Placenta, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Embryo, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-277.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
RN [4]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=29459677; DOI=10.1038/s41588-018-0054-7;
RA Breslow D.K., Hoogendoorn S., Kopp A.R., Morgens D.W., Vu B.K.,
RA Kennedy M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.,
RA Nachury M.V.;
RT "A CRISPR-based screen for Hedgehog signaling provides insights into
RT ciliary function and ciliopathies.";
RL Nat. Genet. 50:460-471(2018).
CC -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling
CC (PubMed:29459677). Required for cilia biogenesis (PubMed:29459677).
CC {ECO:0000269|PubMed:29459677}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000305|PubMed:29459677}; Single-pass type I membrane protein
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC37669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK079517; BAC37669.1; ALT_INIT; mRNA.
DR EMBL; AK160051; BAE35591.1; -; mRNA.
DR EMBL; AK167701; BAE39745.1; -; mRNA.
DR EMBL; AK167838; BAE39859.1; -; mRNA.
DR EMBL; AK167977; BAE39969.1; -; mRNA.
DR EMBL; BC029015; AAH29015.1; -; mRNA.
DR EMBL; BC062180; AAH62180.1; -; mRNA.
DR EMBL; BC094275; AAH94275.1; -; mRNA.
DR CCDS; CCDS26553.1; -.
DR RefSeq; NP_780359.2; NM_175150.3.
DR AlphaFoldDB; Q6P6J9; -.
DR SMR; Q6P6J9; -.
DR STRING; 10090.ENSMUSP00000021959; -.
DR GlyConnect; 2764; 5 N-Linked glycans (3 sites).
DR GlyGen; Q6P6J9; 6 sites, 5 N-linked glycans (3 sites).
DR iPTMnet; Q6P6J9; -.
DR PhosphoSitePlus; Q6P6J9; -.
DR EPD; Q6P6J9; -.
DR MaxQB; Q6P6J9; -.
DR PaxDb; Q6P6J9; -.
DR PeptideAtlas; Q6P6J9; -.
DR PRIDE; Q6P6J9; -.
DR ProteomicsDB; 298392; -.
DR Antibodypedia; 2125; 77 antibodies from 14 providers.
DR Ensembl; ENSMUST00000021959; ENSMUSP00000021959; ENSMUSG00000021497.
DR GeneID; 69672; -.
DR KEGG; mmu:69672; -.
DR UCSC; uc007qry.2; mouse.
DR CTD; 79770; -.
DR MGI; MGI:1916922; Txndc15.
DR VEuPathDB; HostDB:ENSMUSG00000021497; -.
DR eggNOG; KOG2640; Eukaryota.
DR GeneTree; ENSGT00390000002845; -.
DR HOGENOM; CLU_050221_0_0_1; -.
DR InParanoid; Q6P6J9; -.
DR OMA; TCEERNV; -.
DR OrthoDB; 1057290at2759; -.
DR PhylomeDB; Q6P6J9; -.
DR TreeFam; TF323528; -.
DR BioGRID-ORCS; 69672; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Txndc15; mouse.
DR PRO; PR:Q6P6J9; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q6P6J9; protein.
DR Bgee; ENSMUSG00000021497; Expressed in otolith organ and 223 other tissues.
DR Genevisible; Q6P6J9; MM.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IDA:UniProtKB.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:UniProtKB.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR042418; TXNDC15.
DR PANTHER; PTHR14684; PTHR14684; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Cilium biogenesis/degradation;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..344
FT /note="Thioredoxin domain-containing protein 15"
FT /id="PRO_0000296095"
FT TOPO_DOM 21..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 163..280
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT REGION 55..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
SQ SEQUENCE 344 AA; 38146 MW; 1F8603AEADD2015F CRC64;
MQLLCWWQVL LWVLGLPAHG LEVAEDSGHP WREERPVPAL QVGAVYLHEE EVAQDHRDQA
RAAEPMEASL GPRGDPMVVL SVVPGAAEDQ RSPEAHDGTC SAQGEEDPSC GRENLFGLQG
AGGFQDREEE YYAEPGVTEA EPVATEDANS TDSLKSPKVN CEERNVTGLE NFTLKILNMS
QDLMDFLNPN GSDCTLVLFY TPWCRFSASL APHFNSLPRA FPTLGFLALD ASQHSSLSTR
FGTVAVPNIL LFQGAKPMAR FNHTDRTLET LKIFIFNQTG IEAKKNVVVT QADQMGPLPS
TLIKTVDWLL VFSLFFLISF IMYATIRTES IRWLIPGQEQ EHAE
