ID   TXD15_XENLA             Reviewed;         342 AA.
AC   Q0IHI1;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Thioredoxin domain-containing protein 15;
DE   Flags: Precursor;
GN   Name=txndc15;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling.
CC       Required for cilia biogenesis. {ECO:0000250|UniProtKB:Q6P6J9}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000250|UniProtKB:Q6P6J9}; Single-pass type I membrane protein
CC       {ECO:0000255}.
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DR   EMBL; BC123146; AAI23147.1; -; mRNA.
DR   RefSeq; NP_001090310.1; NM_001096841.1.
DR   AlphaFoldDB; Q0IHI1; -.
DR   SMR; Q0IHI1; -.
DR   MaxQB; Q0IHI1; -.
DR   DNASU; 779219; -.
DR   GeneID; 779219; -.
DR   KEGG; xla:779219; -.
DR   CTD; 779219; -.
DR   Xenbase; XB-GENE-987700; txndc15.L.
DR   OMA; MVPREVM; -.
DR   OrthoDB; 1057290at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 779219; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   InterPro; IPR042418; TXNDC15.
DR   PANTHER; PTHR14684; PTHR14684; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..342
FT                   /note="Thioredoxin domain-containing protein 15"
FT                   /id="PRO_0000296097"
FT   TOPO_DOM        22..301
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        323..342
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          173..276
FT                   /note="Thioredoxin"
FT   REGION          120..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..146
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   342 AA;  37951 MW;  264D19696FB9F74F CRC64;
     MRVNVQRWTL YVLLLMSGAR GNQQNEASIV EDQNKKEDNV NLESASISAH PEIAPASEPI
     QYKTAEIADA MQATDIPTNP AVLLSMVPRE VMDLKVSESE SSVCDSTIEE AECSAYEHLN
     EPADAQDKGN SETPERDTEQ AKAEESNNTD SSKPLKVNCE ERNITGISNF TVNILNITQD
     LMEFLNPNSS ECTLVLFYTP WCRFSAGLAP HFNTLPRAFP TLHFLALDAS QHSSLSTRFG
     TVAVPNILLF QGAKPMARFN HTDRKLEALK SFIFNQSGIE AVPGVVVTED DCESPLPCAP
     TVGIDWLLVF SVIYVTIFIV YATMQTESIR WLIPGQEHEH QE