TXD16_HUMAN
ID TXD16_HUMAN Reviewed; 825 AA.
AC Q9P2K2; A5PKW9; A7E260; A7MD07; B9EH67; Q9H9W7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 4.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Thioredoxin domain-containing protein 16 {ECO:0000312|HGNC:HGNC:19965};
DE Flags: Precursor;
GN Name=TXNDC16 {ECO:0000312|HGNC:HGNC:19965};
GN Synonyms=ERP90 {ECO:0000303|PubMed:21359175}, KIAA1344;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-486.
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-486.
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 456-825.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP SUBCELLULAR LOCATION, INTERACTION WITH FOXRED2, DISULFIDE BONDS, AND
RP GLYCOSYLATION.
RX PubMed=21359175; DOI=10.1371/journal.pone.0017037;
RA Riemer J., Hansen H.G., Appenzeller-Herzog C., Johansson L., Ellgaard L.;
RT "Identification of the PDI-family member ERp90 as an interaction partner of
RT ERFAD.";
RL PLoS ONE 6:E17037-E17037(2011).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=25122923; DOI=10.4049/jimmunol.1303098;
RA Harz C., Ludwig N., Lang S., Werner T.V., Galata V., Backes C., Schmitt K.,
RA Nickels R., Krause E., Jung M., Rettig J., Keller A., Menger M.,
RA Zimmermann R., Meese E.;
RT "Secretion and immunogenicity of the meningioma-associated antigen
RT TXNDC16.";
RL J. Immunol. 193:3146-3154(2014).
CC -!- SUBUNIT: Interacts with FOXRED2. {ECO:0000269|PubMed:21359175}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25122923}.
CC Endoplasmic reticulum lumen {ECO:0000269|PubMed:21359175,
CC ECO:0000269|PubMed:25122923}.
CC -!- DOMAIN: Contains a masked and non-functional KDEL endoplasmic reticulum
CC retrieval motif. {ECO:0000269|PubMed:25122923}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:21359175}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14101.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB037765; BAA92582.2; -; mRNA.
DR EMBL; CH471078; EAW65650.1; -; Genomic_DNA.
DR EMBL; BC137081; AAI37082.1; -; mRNA.
DR EMBL; BC137082; AAI37083.1; -; mRNA.
DR EMBL; BC142650; AAI42651.1; -; mRNA.
DR EMBL; BC150205; AAI50206.1; -; mRNA.
DR EMBL; BC152428; AAI52429.1; -; mRNA.
DR EMBL; AK022563; BAB14101.1; ALT_INIT; mRNA.
DR CCDS; CCDS32083.1; -.
DR RefSeq; NP_001153519.1; NM_001160047.1.
DR RefSeq; NP_065835.2; NM_020784.2.
DR AlphaFoldDB; Q9P2K2; -.
DR SMR; Q9P2K2; -.
DR BioGRID; 121602; 58.
DR IntAct; Q9P2K2; 29.
DR STRING; 9606.ENSP00000281741; -.
DR GlyGen; Q9P2K2; 1 site.
DR iPTMnet; Q9P2K2; -.
DR PhosphoSitePlus; Q9P2K2; -.
DR BioMuta; TXNDC16; -.
DR DMDM; 212276524; -.
DR EPD; Q9P2K2; -.
DR MassIVE; Q9P2K2; -.
DR MaxQB; Q9P2K2; -.
DR PaxDb; Q9P2K2; -.
DR PeptideAtlas; Q9P2K2; -.
DR PRIDE; Q9P2K2; -.
DR ProteomicsDB; 83828; -.
DR Antibodypedia; 149; 36 antibodies from 16 providers.
DR DNASU; 57544; -.
DR Ensembl; ENST00000281741.9; ENSP00000281741.4; ENSG00000087301.9.
DR GeneID; 57544; -.
DR KEGG; hsa:57544; -.
DR MANE-Select; ENST00000281741.9; ENSP00000281741.4; NM_020784.3; NP_065835.2.
DR UCSC; uc001wzs.4; human.
DR CTD; 57544; -.
DR DisGeNET; 57544; -.
DR GeneCards; TXNDC16; -.
DR HGNC; HGNC:19965; TXNDC16.
DR HPA; ENSG00000087301; Low tissue specificity.
DR MIM; 616179; gene.
DR neXtProt; NX_Q9P2K2; -.
DR OpenTargets; ENSG00000087301; -.
DR PharmGKB; PA162407488; -.
DR VEuPathDB; HostDB:ENSG00000087301; -.
DR eggNOG; KOG0191; Eukaryota.
DR GeneTree; ENSGT00390000006080; -.
DR HOGENOM; CLU_018100_1_0_1; -.
DR InParanoid; Q9P2K2; -.
DR OMA; HANVVFK; -.
DR OrthoDB; 1124691at2759; -.
DR PhylomeDB; Q9P2K2; -.
DR TreeFam; TF328825; -.
DR PathwayCommons; Q9P2K2; -.
DR SignaLink; Q9P2K2; -.
DR BioGRID-ORCS; 57544; 9 hits in 1075 CRISPR screens.
DR ChiTaRS; TXNDC16; human.
DR GenomeRNAi; 57544; -.
DR Pharos; Q9P2K2; Tdark.
DR PRO; PR:Q9P2K2; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9P2K2; protein.
DR Bgee; ENSG00000087301; Expressed in seminal vesicle and 177 other tissues.
DR ExpressionAtlas; Q9P2K2; baseline and differential.
DR Genevisible; Q9P2K2; HS.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR040090; TXNDC16.
DR PANTHER; PTHR22699; PTHR22699; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255, ECO:0000269|PubMed:25122923"
FT CHAIN 28..825
FT /note="Thioredoxin domain-containing protein 16"
FT /id="PRO_0000257789"
FT DOMAIN 392..495
FT /note="Thioredoxin"
FT REGION 762..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 816..819
FT /note="Mediates endoplasmic reticulum retention"
FT /evidence="ECO:0000269|PubMed:25122923"
FT COMPBIAS 763..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 460
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 449..456
FT /evidence="ECO:0000269|PubMed:21359175"
FT VARIANT 136
FT /note="S -> N (in dbSNP:rs28759013)"
FT /id="VAR_061899"
FT VARIANT 152
FT /note="N -> Y (in dbSNP:rs28593180)"
FT /id="VAR_061900"
FT VARIANT 486
FT /note="E -> K (in dbSNP:rs7155490)"
FT /evidence="ECO:0000269|PubMed:10718198,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_028919"
FT CONFLICT 180
FT /note="A -> G (in Ref. 1; BAA92582)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 825 AA; 93572 MW; B86F6DA47B5098D6 CRC64;
MFSGFNVFRV GISFVIMCIF YMPTVNSLPE LSPQKYFSTL QPGKASLAYF CQADSPRTSV
FLEELNEAVR PLQDYGISVA KVNCVKEEIS RYCGKEKDLM KAYLFKGNIL LREFPTDTLF
DVNAIVAHVL FALLFSEVKY ITNLEDLQNI ENALKGKANI IFSYVRAIGI PEHRAVMEAA
FVYGTTYQFV LTTEIALLES IGSEDVEYAH LYFFHCKLVL DLTQQCRRTL MEQPLTTLNI
HLFIKTMKAP LLTEVAEDPQ QVSTVHLQLG LPLVFIVSQQ ATYEADRRTA EWVAWRLLGK
AGVLLLLRDS LEVNIPQDAN VVFKRAEEGV PVEFLVLHDV DLIISHVENN MHIEEIQEDE
DNDMEGPDID VQDDEVAETV FRDRKRKLPL ELTVELTEET FNATVMASDS IVLFYAGWQA
VSMAFLQSYI DVAVKLKGTS TMLLTRINCA DWSDVCTKQN VTEFPIIKMY KKGENPVSYA
GMLGTEDLLK FIQLNRISYP VNITSIQEAE EYLSGELYKD LILYSSVSVL GLFSPTMKTA
KEDFSEAGNY LKGYVITGIY SEEDVLLLST KYAASLPALL LARHTEGKIE SIPLASTHAQ
DIVQIITDAL LEMFPEITVE NLPSYFRLQK PLLILFSDGT VNPQYKKAIL TLVKQKYLDS
FTPCWLNLKN TPVGRGILRA YFDPLPPLPL LVLVNLHSGG QVFAFPSDQA IIEENLVLWL
KKLEAGLENH ITILPAQEWK PPLPAYDFLS MIDAATSQRG TRKVPKCMKE TDVQENDKEQ
HEDKSAVRKE PIETLRIKHW NRSNWFKEAE KSFRRDKELG CSKVN
