ID   TXD17_DANRE             Reviewed;         123 AA.
AC   Q6DBT3;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Thioredoxin domain-containing protein 17;
DE   AltName: Full=Thioredoxin-like protein 5;
GN   Name=txndc17; Synonyms=txnl5; ORFNames=zgc:91920;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Disulfide reductase. May participate in various redox
CC       reactions through the reversible oxidation of its active center dithiol
CC       to a disulfide and catalyze dithiol-disulfide exchange reactions. Has
CC       peroxidase activity and may contribute to the elimination of cellular
CC       hydrogen peroxide (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; BC078373; AAH78373.1; -; mRNA.
DR   RefSeq; NP_001003456.1; NM_001003456.1.
DR   AlphaFoldDB; Q6DBT3; -.
DR   SMR; Q6DBT3; -.
DR   STRING; 7955.ENSDARP00000075336; -.
DR   PaxDb; Q6DBT3; -.
DR   Ensembl; ENSDART00000080892; ENSDARP00000075336; ENSDARG00000058079.
DR   GeneID; 445062; -.
DR   KEGG; dre:445062; -.
DR   CTD; 84817; -.
DR   ZFIN; ZDB-GENE-040801-193; txndc17.
DR   eggNOG; KOG3425; Eukaryota.
DR   GeneTree; ENSGT00390000012195; -.
DR   HOGENOM; CLU_120161_0_1_1; -.
DR   InParanoid; Q6DBT3; -.
DR   OMA; IMVVTHN; -.
DR   OrthoDB; 1624076at2759; -.
DR   PhylomeDB; Q6DBT3; -.
DR   TreeFam; TF313854; -.
DR   PRO; PR:Q6DBT3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 15.
DR   Bgee; ENSDARG00000058079; Expressed in intestine and 23 other tissues.
DR   ExpressionAtlas; Q6DBT3; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0047134; F:protein-disulfide reductase (NAD(P)) activity; IBA:GO_Central.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR045108; TXNDC17-like.
DR   InterPro; IPR010357; TXNDC17_dom.
DR   PANTHER; PTHR12452; PTHR12452; 1.
DR   Pfam; PF06110; DUF953; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Disulfide bond; Redox-active center; Reference proteome.
FT   CHAIN           1..123
FT                   /note="Thioredoxin domain-containing protein 17"
FT                   /id="PRO_0000120025"
FT   DOMAIN          41..123
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        43
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRA2"
FT   ACT_SITE        46
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRA2"
FT   SITE            44
FT                   /note="Contributes to redox potential value"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRA2"
FT   SITE            45
FT                   /note="Contributes to redox potential value"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRA2"
FT   DISULFID        43..46
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRA2"
SQ   SEQUENCE   123 AA;  14193 MW;  2A9C644179392553 CRC64;
     MSKYEEVAVH GYEEFCKAVS DRKGKEIFAY FSGDKDEHGK SWCPDCVKAE PVVRAELPHL
     PEGTVFIYCQ VGDRPYWKDS NNDFKKTLKL TGVPTLLRYG TPQKLVEEEC FKADLVRMMF
     TED