TXD2B_SCOMU
ID TXD2B_SCOMU Reviewed; 76 AA.
AC I6RU37;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 1.
DT 25-MAY-2022, entry version 17.
DE RecName: Full=Omega-scoloptoxin(13)-Ssm2b {ECO:0000250|UniProtKB:I6S390};
DE Short=Omega-SLPTX(13)-Ssm2b {ECO:0000250|UniProtKB:I6S390};
DE AltName: Full=Omega-scoloptoxin-Ssm2b {ECO:0000303|PubMed:22595790};
DE Short=Omega-SLPTX-Ssm2b {ECO:0000303|PubMed:22595790};
DE Flags: Precursor;
OS Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS subspinipes mutilans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX NCBI_TaxID=2836329;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=22595790; DOI=10.1074/mcp.m112.018853;
RA Yang S., Liu Z., Xiao Y., Li Y., Rong M., Liang S., Zhang Z., Yu H.,
RA King G.F., Lai R.;
RT "Chemical punch packed in venoms makes centipedes excellent predators.";
RL Mol. Cell. Proteomics 11:640-650(2012).
CC -!- FUNCTION: Inhibits voltage-gated calcium channel (Cav) currents.
CC {ECO:0000250|UniProtKB:I6S390}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22595790}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:22595790}.
CC -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the scoloptoxin-13 family. {ECO:0000305}.
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DR EMBL; JQ757061; AFM55008.1; -; mRNA.
DR AlphaFoldDB; I6RU37; -.
DR SMR; I6RU37; -.
DR PRIDE; I6RU37; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Calcium channel impairing toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin;
KW Voltage-gated calcium channel impairing toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..76
FT /note="Omega-scoloptoxin(13)-Ssm2b"
FT /evidence="ECO:0000250|UniProtKB:I6S390"
FT /id="PRO_0000425467"
SQ SEQUENCE 76 AA; 8453 MW; 6BB7FFCA41D0A11E CRC64;
MAYIYALIFA IVVCMNTDVI QAEESQHDTL ENVEYRLSCI PKGGECERMA DPCCPGLQCL
GGNPFNKENF GKCKCQ