ID   TXE02_LYCSI             Reviewed;          87 AA.
AC   B6DD35;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=U14-lycotoxin-Ls1a;
DE   AltName: Full=Toxin-like structure LSTX-N2;
DE   Flags: Precursor;
OS   Lycosa singoriensis (Wolf spider) (Aranea singoriensis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Lycosa.
OX   NCBI_TaxID=434756;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19875276; DOI=10.1016/j.zool.2009.04.001;
RA   Zhang Y., Chen J., Tang X., Wang F., Jiang L., Xiong X., Wang M., Rong M.,
RA   Liu Z., Liang S.;
RT   "Transcriptome analysis of the venom glands of the Chinese wolf spider
RT   Lycosa singoriensis.";
RL   Zoology 113:10-18(2010).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the venom protein 11 family. 01 (wap-1)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU926119; ACI41451.1; -; mRNA.
DR   EMBL; FM864123; CAS03720.1; -; mRNA.
DR   AlphaFoldDB; B6DD35; -.
DR   SMR; B6DD35; -.
DR   ArachnoServer; AS001057; U14-lycotoxin-Ls1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   SUPFAM; SSF57256; SSF57256; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..87
FT                   /note="U14-lycotoxin-Ls1a"
FT                   /id="PRO_0000401878"
FT   DOMAIN          21..66
FT                   /note="WAP"
FT   DISULFID        24..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..80
FT                   /evidence="ECO:0000305"
FT   DISULFID        47..62
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   87 AA;  9581 MW;  E4F786FF99C2067E CRC64;
     MNSKVFAALL LLALSTCVLS EKYCPTPRNT SCKKMNIRNN CCRDSDCTSN AFCCAEPCGN
     FCHKASDKPG GRRVDPNASC QTGYVYW