ID   TXF28_CTEON             Reviewed;          44 AA.
AC   P85033;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=U4-ctenitoxin-Co1a;
DE            Short=U4-CNTX-Co1a;
DE   AltName: Full=Neurotoxin Oc M27-11;
DE   AltName: Full=Neurotoxin Oct F28-8;
DE   Flags: Fragment;
OS   Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX   NCBI_TaxID=406443;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|Ref.1};
RA   Richardson M., Goncalves J.M., Borges M.H., Oliveira C.F.B.,
RA   Bemquerer M.P., Rates B.A., Pimenta A.M.C., Cordeiro M.N.;
RT   "Protein Oct F28-8 from venom of spider Oligoctenus ornatus has strong
RT   sequence similarities with Tx3-4 neurotoxins from Phoneutria spiders.";
RL   Submitted (OCT-2006) to UniProtKB.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-26, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom;
RA   Borges M.H., Oliveira C.F.B., Goncalves J.M., Rates B., Santos D.M.,
RA   Pimenta A.M.C., Cordeiro M.N., Richardson M.;
RL   Submitted (JUL-2007) to UniProtKB.
CC   -!- FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium
CC       channels (Cav) (By similarity). Toxic to mice by
CC       intracerebroventricular injection. {ECO:0000250, ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1, ECO:0000269|Ref.2}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1,
CC       ECO:0000269|Ref.2}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=8592.95; Mass_error=0.1; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- MASS SPECTROMETRY: Mass=8594; Mass_error=1.25; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.2};
CC   -!- SIMILARITY: Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type
CC       II/III omega-agtx) subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P85033; -.
DR   ArachnoServer; AS000311; U4-ctenitoxin-Co1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR005853; Omega-agatoxin_II/III_CS.
DR   InterPro; IPR013605; Toxin_34.
DR   Pfam; PF08396; Toxin_34; 1.
DR   PROSITE; PS60023; OMEGA_AGA_II_III; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   CHAIN           1..>44
FT                   /note="U4-ctenitoxin-Co1a"
FT                   /id="PRO_0000262765"
FT   DISULFID        2..19
FT                   /evidence="ECO:0000305"
FT   DISULFID        9..25
FT                   /evidence="ECO:0000305"
FT   DISULFID        18..39
FT                   /evidence="ECO:0000305"
FT   DISULFID        27..37
FT                   /evidence="ECO:0000305"
FT   NON_TER         44
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   44 AA;  4814 MW;  5FE3885ED005DF10 CRC64;
     SCIKHGDFCD GDKDDCQCCR DNGFCSCSGI FGLKWNCRCD VGTT