TXF2A_SCODE
ID TXF2A_SCODE Reviewed; 92 AA.
AC P0DQC1;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=Kappa-scoloptoxin(15)-Ssd2a {ECO:0000303|PubMed:24847043, ECO:0000305};
DE Short=Kappa-SLPTX(15)-Ssd2a {ECO:0000303|PubMed:24847043, ECO:0000305};
DE AltName: Full=Toxin SSD559 {ECO:0000303|PubMed:23148443};
DE Flags: Precursor;
OS Scolopendra dehaani (Thai centipede) (Scolopendra subspinipes dehaani).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX NCBI_TaxID=2609776;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-46, SUBCELLULAR
RP LOCATION, MASS SPECTROMETRY, AND FUNCTION.
RC TISSUE=Venom, and Venom gland;
RX PubMed=23148443; DOI=10.1021/pr300881d;
RA Liu Z.C., Zhang R., Zhao F., Chen Z.M., Liu H.W., Wang Y.J., Jiang P.,
RA Zhang Y., Wu Y., Ding J.P., Lee W.H., Zhang Y.;
RT "Venomic and transcriptomic analysis of centipede Scolopendra subspinipes
RT dehaani.";
RL J. Proteome Res. 11:6197-6212(2012).
RN [2]
RP NOMENCLATURE.
RX PubMed=24847043; DOI=10.1093/molbev/msu162;
RA Undheim E.A., Jones A., Clauser K.R., Holland J.W., Pineda S.S., King G.F.,
RA Fry B.G.;
RT "Clawing through evolution: toxin diversification and convergence in the
RT ancient lineage Chilopoda (centipedes).";
RL Mol. Biol. Evol. 31:2124-2148(2014).
CC -!- FUNCTION: Inhibits voltage-gated potassium channels (Kv) (IC(50)=about
CC 10 nM), when tested on DRG neurons. {ECO:0000269|PubMed:23148443}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23148443}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:23148443}.
CC -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=8556.2; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:23148443};
CC -!- SIMILARITY: Belongs to the scoloptoxin-15 family. {ECO:0000305}.
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DR EMBL; KC144556; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0DQC1; -.
DR SMR; P0DQC1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:23148443"
FT CHAIN 21..92
FT /note="Kappa-scoloptoxin(15)-Ssd2a"
FT /evidence="ECO:0000305"
FT /id="PRO_0000446795"
SQ SEQUENCE 92 AA; 10677 MW; CD703E2D3D61B793 CRC64;
MKMVYLGLFL IITSCVISSG NLIYECKWAD SIRLKDKNPT HEFCKKKCEE KNTDRITVQH
GFHSSDYRCT CQGEKILETP YQSDGVKDCH RI