ID   TXG1D_CHIGU             Reviewed;          36 AA.
AC   P84836;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Kappa-theraphotoxin-Pg1b;
DE            Short=Kappa-TRTX-Pg1b;
DE   AltName: Full=Guangxitoxin-1D;
DE            Short=GxTX-1D;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=16567526; DOI=10.2337/diabetes.55.04.06.db05-0788;
RA   Herrington J., Zhou Y.-P., Bugianesi R.M., Dulski P.M., Feng Y.,
RA   Warren V.A., Smith M.M., Kohler M.G., Garsky V.M., Sanchez M., Wagner M.,
RA   Raphaelli K., Banerjee P., Ahaghotu C., Wunderler D., Priest B.T.,
RA   Mehl J.T., Garcia M.L., McManus O.B., Kaczorowski G.J., Slaughter R.S.;
RT   "Blockers of the delayed-rectifier potassium current in pancreatic beta-
RT   cells enhance glucose-dependent insulin secretion.";
RL   Diabetes 55:1034-1042(2006).
RN   [2]
RP   ERRATUM OF PUBMED:16567526.
RA   Herrington J., Zhou Y.-P., Bugianesi R.M., Dulski P.M., Feng Y.,
RA   Warren V.A., Smith M.M., Kohler M.G., Garsky V.M., Sanchez M., Wagner M.,
RA   Raphaelli K., Banerjee P., Ahaghotu C., Wunderler D., Priest B.T.,
RA   Mehl J.T., Garcia M.L., McManus O.B., Kaczorowski G.J., Slaughter R.S.;
RL   Diabetes 55:1904-1904(2006).
CC   -!- FUNCTION: Gating modifier of Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3
CC       channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16567526}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:16567526}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=3934; Mass_error=0.39; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16567526};
CC   -!- MISCELLANEOUS: Blockers of Kv2.1/KCNB1 potassium channels may be a
CC       useful approach to the design of novel therapeutic agents for the
CC       treatment of type 2 diabetes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 44 (Jztx-4)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P84836; -.
DR   BMRB; P84836; -.
DR   SMR; P84836; -.
DR   ArachnoServer; AS000322; kappa-theraphotoxin-Pg1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   Pfam; PF07740; Toxin_12; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..36
FT                   /note="Kappa-theraphotoxin-Pg1b"
FT                   /evidence="ECO:0000269|PubMed:16567526"
FT                   /id="PRO_0000233917"
FT   DISULFID        4..19
FT                   /evidence="ECO:0000250|UniProtKB:P62520"
FT   DISULFID        11..24
FT                   /evidence="ECO:0000250|UniProtKB:P62520"
FT   DISULFID        18..31
FT                   /evidence="ECO:0000250|UniProtKB:P62520"
SQ   SEQUENCE   36 AA;  3941 MW;  9905D00B9A24AEB9 CRC64;
     DGECGGFWWK CGSGKPACCP KYVCSPKWGL CNFPMP