TXG2A_ETHRU
ID TXG2A_ETHRU Reviewed; 120 AA.
AC P0DQC5;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 25-MAY-2022, entry version 5.
DE RecName: Full=U-scoloptoxin(16)-Er2a {ECO:0000303|PubMed:24847043};
DE Short=U-SLPTX(16)-Er2a {ECO:0000303|PubMed:24847043};
DE Flags: Precursor;
OS Ethmostigmus rubripes (Giant centipede).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Scolopendromorpha; Scolopendridae; Ethmostigmus.
OX NCBI_TaxID=62613;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND NOMENCLATURE.
RC TISSUE=Venom gland;
RX PubMed=24847043; DOI=10.1093/molbev/msu162;
RA Undheim E.A., Jones A., Clauser K.R., Holland J.W., Pineda S.S., King G.F.,
RA Fry B.G.;
RT "Clawing through evolution: toxin diversification and convergence in the
RT ancient lineage Chilopoda (centipedes).";
RL Mol. Biol. Evol. 31:2124-2148(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24847043}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:24847043}.
CC -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the scoloptoxin-16 family. {ECO:0000305}.
CC -!- CAUTION: All E.rubripes family members described in 'Undeheim et al.,
CC 2014' have not been imported into UniProtKB. Please, refer to this
CC paper to access them. {ECO:0000305|PubMed:24847043}.
CC -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC (NCBI);
CC URL="https://www.ncbi.nlm.nih.gov/nuccore/GASI01000135";
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DR AlphaFoldDB; P0DQC5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR029277; SVWC_dom.
DR Pfam; PF15430; SVWC; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..120
FT /note="U-scoloptoxin(16)-Er2a"
FT /evidence="ECO:0000305"
FT /id="PRO_0000446806"
SQ SEQUENCE 120 AA; 13212 MW; 83780C7565162576 CRC64;
MNTVSVVQFL AVGCAVFVLY GRGVFAAEGV KKAGQHKDAE LCLGSDGLGH RLDEFWYNDD
MCQRFLCFKD DEGIMYEQIA NCPIAIAEGD CTLKPGTKGH YPDCCPAVEC PPEDQKEEEI