ID   TXG2_CHIGU              Reviewed;          33 AA.
AC   P84837;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Kappa-theraphotoxin-Pg2a;
DE            Short=Kappa-TRTX-Pg2a;
DE   AltName: Full=Guangxitoxin-2 {ECO:0000303|PubMed:16567526};
DE            Short=GxTX-2 {ECO:0000303|PubMed:16567526};
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=16567526; DOI=10.2337/diabetes.55.04.06.db05-0788;
RA   Herrington J., Zhou Y.-P., Bugianesi R.M., Dulski P.M., Feng Y.,
RA   Warren V.A., Smith M.M., Kohler M.G., Garsky V.M., Sanchez M., Wagner M.,
RA   Raphaelli K., Banerjee P., Ahaghotu C., Wunderler D., Priest B.T.,
RA   Mehl J.T., Garcia M.L., McManus O.B., Kaczorowski G.J., Slaughter R.S.;
RT   "Blockers of the delayed-rectifier potassium current in pancreatic beta-
RT   cells enhance glucose-dependent insulin secretion.";
RL   Diabetes 55:1034-1042(2006).
RN   [2]
RP   ERRATUM OF PUBMED:16567526.
RA   Herrington J., Zhou Y.-P., Bugianesi R.M., Dulski P.M., Feng Y.,
RA   Warren V.A., Smith M.M., Kohler M.G., Garsky V.M., Sanchez M., Wagner M.,
RA   Raphaelli K., Banerjee P., Ahaghotu C., Wunderler D., Priest B.T.,
RA   Mehl J.T., Garcia M.L., McManus O.B., Kaczorowski G.J., Slaughter R.S.;
RL   Diabetes 55:1904-1904(2006).
CC   -!- FUNCTION: Gating modifier of Kv2.1/KCNB1 channels.
CC       {ECO:0000269|PubMed:16567526}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16567526}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:16567526}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=3581; Mass_error=0.36; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16567526};
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 28 (Jztx-11)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P84837; -.
DR   SMR; P84837; -.
DR   ArachnoServer; AS000324; kappa-theraphotoxin-Pg2a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   Pfam; PF07740; Toxin_12; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..33
FT                   /note="Kappa-theraphotoxin-Pg2a"
FT                   /id="PRO_0000233919"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:P56855"
FT   DISULFID        9..21
FT                   /evidence="ECO:0000250|UniProtKB:P56855"
FT   DISULFID        15..28
FT                   /evidence="ECO:0000250|UniProtKB:P56855"
SQ   SEQUENCE   33 AA;  3586 MW;  0851C6DADA0C5EF4 CRC64;
     ECRKMFGGCS VDSDCCAHLG CKPTLKYCAW DGT