ID   TXGRX_BUNCN             Reviewed;          21 AA.
AC   P58305;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Granulitoxin {ECO:0000303|PubMed:9876306};
DE            Short=GRX {ECO:0000303|PubMed:9876306};
DE   Flags: Fragment;
OS   Bunodosoma cangicum (Sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Bunodosoma.
OX   NCBI_TaxID=138296;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, TOXIC DOSE, AND MASS SPECTROMETRY.
RC   TISSUE=Nematoblast;
RX   PubMed=9876306; DOI=10.1590/s0100-879x1998001000015;
RA   Santana A.N.C., Leite A.B., Franca M.S., Franca L., Vale O.C., Cunha R.B.,
RA   Ricart C.A.O., Sousa M.V., Carvalho K.M.;
RT   "Partial sequence and toxic effects of granulitoxin, a neurotoxic peptide
RT   from the sea anemone Bundosoma granulifera.";
RL   Braz. J. Med. Biol. Res. 31:1335-1338(1998).
CC   -!- FUNCTION: Injection into mice produces severe neurotoxic effects such
CC       as circular movements, aggressive behavior, dyspnea, tonic-clonic
CC       convulsion and death. {ECO:0000269|PubMed:9876306}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:9876306}. Nematocyst
CC       {ECO:0000305|PubMed:9876306}.
CC   -!- MASS SPECTROMETRY: Mass=4958; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:9876306};
CC   -!- TOXIC DOSE: LD(50) is 400 +/- 83 ug/kg by intraperitoneal injection
CC       into mice. {ECO:0000269|PubMed:9876306}.
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DR   AlphaFoldDB; P58305; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Nematocyst; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..>21
FT                   /note="Granulitoxin"
FT                   /id="PRO_0000045116"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         21
SQ   SEQUENCE   21 AA;  1961 MW;  F58964DC27B1B377 CRC64;
     AKTGILDSDG PTVAGNSLSG T