ID   TXH23_CYRSC             Reviewed;          83 AA.
AC   Q86C49;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=U1-theraphotoxin-Hs1f;
DE            Short=U1-TRTX-Hs1f;
DE   AltName: Full=Huwentoxin-2a;
DE   AltName: Full=Huwentoxin-IIa;
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Diao J., Liang S.;
RT   "cDNA sequence analysis of five peptide toxins from the spider Selenocosmia
RT   huwena: they could be classified into two different superfamilies according
RT   to the prepro region.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lethal neurotoxin that blocks neuromuscular transmission.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY263710; AAP33077.1; -; mRNA.
DR   AlphaFoldDB; Q86C49; -.
DR   SMR; Q86C49; -.
DR   ArachnoServer; AS000336; U1-theraphotoxin-Hs1f.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Neurotoxin; Postsynaptic neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..48
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035525"
FT   CHAIN           49..83
FT                   /note="U1-theraphotoxin-Hs1f"
FT                   /id="PRO_0000035526"
FT   DISULFID        51..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..80
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   83 AA;  9168 MW;  9900652538B95F9E CRC64;
     MKVTLIAILT CAAVLVLHTT AAEELEESQL MEVGMPDTEL AAVDEERLFE CSISCEIEKK
     GESCKPKKCK GGWKCKFNMC VKV