ID   TXH6_CYRSC              Reviewed;          41 AA.
AC   P68420;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=U3-theraphotoxin-Hs1a;
DE            Short=U3-TRTX-Hs1a;
DE   AltName: Full=Huwentoxin-6;
DE   AltName: Full=Huwentoxin-VI;
DE            Short=HwTx-VI;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RA   Yi T.F., Hu W.J., Liang S.-P.;
RT   "Purification and identification of huwentoxin-VI, a neurotoxin peptide
RT   from the venom of S.huwena.";
RL   Dong Wu Xue Yan Jiu 23:463-466(2002).
RN   [2]
RP   REVIEW.
RX   PubMed=15066414; DOI=10.1016/j.toxicon.2004.02.005;
RA   Liang S.-P.;
RT   "An overview of peptide toxins from the venom of the Chinese bird spider
RT   Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)].";
RL   Toxicon 43:575-585(2004).
CC   -!- FUNCTION: Intracerebroventricular injection paralyzes mice. Has no
CC       effect on voltage-gated sodium currents.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 01 (HNTX-16)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P68420; -.
DR   SMR; P68420; -.
DR   ArachnoServer; AS000334; U3-theraphotoxin-Hs1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   InterPro; IPR012627; Toxin_22.
DR   Pfam; PF08092; Toxin_22; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..41
FT                   /note="U3-theraphotoxin-Hs1a"
FT                   /id="PRO_0000087652"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..37
FT                   /evidence="ECO:0000250"
FT   DISULFID        17..40
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   41 AA;  4632 MW;  FBB5051165C87612 CRC64;
     NCIGEQVPCD ENDPRCCSGL VVLKKTLHGI WIKSSYCYKC K