ID   TXH7_CYRSC              Reviewed;          84 AA.
AC   P68421;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=U1-theraphotoxin-Hs1a;
DE            Short=U1-TRTX-Hs1a;
DE   AltName: Full=Huwentoxin-7;
DE   AltName: Full=Huwentoxin-VII;
DE            Short=HwTx-VII;
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=14757201; DOI=10.1016/j.toxicon.2003.08.007;
RA   Diao J., Lin Y., Tang J., Liang S.-P.;
RT   "cDNA sequence analysis of seven peptide toxins from the spider
RT   Selenocosmia huwena.";
RL   Toxicon 42:715-723(2003).
RN   [2]
RP   PROTEIN SEQUENCE OF 49-84, AND CHARACTERIZATION.
RC   TISSUE=Venom;
RA   Dai J., Liang S.-P.;
RT   "Purification and characterization of HWTX-VII and HWTX-VIII: two novel
RT   insecticidal neurotoxins from the Chinese bird spider Selenocosmia
RT   huwena.";
RL   Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 19:71-75(2003).
RN   [3]
RP   REVIEW.
RX   PubMed=15066414; DOI=10.1016/j.toxicon.2004.02.005;
RA   Liang S.-P.;
RT   "An overview of peptide toxins from the venom of the Chinese bird spider
RT   Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)].";
RL   Toxicon 43:575-585(2004).
CC   -!- FUNCTION: Blocks neuromuscular transmission. Acts cooperatively to
CC       potentiate the activity of huwentoxin-I. Paralyzes locusts and kills
CC       mice following intracerebroventricular injection.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P68421; -.
DR   SMR; P68421; -.
DR   ArachnoServer; AS000328; U1-theraphotoxin-Hs1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..48
FT                   /evidence="ECO:0000269|Ref.2"
FT                   /id="PRO_0000035527"
FT   CHAIN           49..84
FT                   /note="U1-theraphotoxin-Hs1a"
FT                   /id="PRO_0000035528"
FT   DISULFID        51..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..76
FT                   /evidence="ECO:0000250"
FT   DISULFID        70..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   84 AA;  9358 MW;  C7DABDFED95CAFA3 CRC64;
     MKVTLIAILT CAAVLVLHTT AAEELEESQL MEVGMPDTEL AAVDEERLFE CSFSCEIEKE
     GDKPCKKKKC KGGWKCKFNM CVKV