TXH8_CYRSC
ID TXH8_CYRSC Reviewed; 35 AA.
AC P68422;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=U1-theraphotoxin-Hs1f;
DE Short=U1-TRTX-Hs1f;
DE AltName: Full=Huwentoxin-8;
DE AltName: Full=Huwentoxin-VIII;
DE Short=HwTx-VIII;
OS Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Cyriopagopus.
OX NCBI_TaxID=29017;
RN [1]
RP PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC TISSUE=Venom;
RA Dai J., Liang S.-P.;
RT "Purification and characterization of HWTX-VII and HWTX-VIII: two novel
RT insecticidal neurotoxins from the Chinese bird spider Selenocosmia
RT huwena.";
RL Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 19:71-75(2003).
RN [2]
RP REVIEW.
RX PubMed=15066414; DOI=10.1016/j.toxicon.2004.02.005;
RA Liang S.-P.;
RT "An overview of peptide toxins from the venom of the Chinese bird spider
RT Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)].";
RL Toxicon 43:575-585(2004).
CC -!- FUNCTION: Blocks neuromuscular transmission. Acts cooperatively to
CC potentiate the activity of huwentoxin-I. Paralyzes locusts and kills
CC mice following intracerebroventricular injection.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2)
CC subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P68422; -.
DR SMR; P68422; -.
DR ArachnoServer; AS000336; U1-theraphotoxin-Hs1f.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR012625; Toxin_20.
DR Pfam; PF08089; Toxin_20; 1.
DR PROSITE; PS60022; HWTX_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Neurotoxin;
KW Postsynaptic neurotoxin; Secreted; Toxin.
FT PEPTIDE 1..35
FT /note="U1-theraphotoxin-Hs1f"
FT /id="PRO_0000044984"
FT DISULFID 3..16
FT /evidence="ECO:0000250"
FT DISULFID 7..27
FT /evidence="ECO:0000250"
FT DISULFID 21..32
FT /evidence="ECO:0000250"
SQ SEQUENCE 35 AA; 3987 MW; 4A45D8BCFB663EA3 CRC64;
FECSISCEIE KKGESCKPKK CKGGWKCKFN MCVKV