ID   TXH9_CYRSC              Reviewed;          34 AA.
AC   P68423;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=U4-theraphotoxin-Hs1a;
DE            Short=U4-TRTX-Hs1a;
DE   AltName: Full=Huwentoxin-9;
DE   AltName: Full=Huwentoxin-IX;
DE            Short=HwTx-IX;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   PROTEIN SEQUENCE, AND REVIEW.
RX   PubMed=15066414; DOI=10.1016/j.toxicon.2004.02.005;
RA   Liang S.-P.;
RT   "An overview of peptide toxins from the venom of the Chinese bird spider
RT   Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)].";
RL   Toxicon 43:575-585(2004).
CC   -!- FUNCTION: Intracisternal injection paralyzes mice.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 05 (ICK-7)
CC       subfamily.
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DR   AlphaFoldDB; P68423; -.
DR   SMR; P68423; -.
DR   ArachnoServer; AS000337; U4-theraphotoxin-Hs1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted; Toxin.
FT   PEPTIDE         1..34
FT                   /note="U4-theraphotoxin-Hs1a"
FT                   /id="PRO_0000045009"
FT   DISULFID        3..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..22
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..33
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   34 AA;  3137 MW;  313DF103F7D6E267 CRC64;
     IICAPEGGPC VAGIGCCAGL RCSGAKLGLA GSCQ