TXIP1_HUMAN
ID TXIP1_HUMAN Reviewed; 658 AA.
AC Q2TAA8; Q9P105;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Translin-associated factor X-interacting protein 1;
DE Short=Trax-interacting protein 1;
GN Name=TSNAXIP1 {ECO:0000312|EMBL:AAI11019.1}; Synonyms=TXI1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAF66441.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.;
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF66441.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAI11019.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain {ECO:0000312|EMBL:AAI11019.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible role in spermatogenesis.
CC {ECO:0000250|UniProtKB:Q99P25}.
CC -!- SUBUNIT: Interacts with TSNAX. {ECO:0000250|UniProtKB:Q99P25}.
CC -!- INTERACTION:
CC Q2TAA8; O00311: CDC7; NbExp=3; IntAct=EBI-6872498, EBI-374980;
CC Q2TAA8; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-6872498, EBI-7225287;
CC Q2TAA8; Q99633: PRPF18; NbExp=3; IntAct=EBI-6872498, EBI-2798416;
CC Q2TAA8; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-6872498, EBI-742688;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:Q99P25}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:15489334};
CC IsoId=Q2TAA8-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15489334};
CC IsoId=Q2TAA8-2; Sequence=VSP_052710;
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DR EMBL; AF132730; AAF66441.1; -; mRNA.
DR EMBL; CH471092; EAW83169.1; -; Genomic_DNA.
DR EMBL; CH471092; EAW83174.1; -; Genomic_DNA.
DR EMBL; BC111018; AAI11019.1; -; mRNA.
DR CCDS; CCDS10846.2; -. [Q2TAA8-1]
DR RefSeq; NP_001275921.1; NM_001288992.1. [Q2TAA8-2]
DR RefSeq; NP_001275922.1; NM_001288993.1. [Q2TAA8-2]
DR RefSeq; NP_001275923.1; NM_001288994.1. [Q2TAA8-2]
DR RefSeq; NP_060900.2; NM_018430.3. [Q2TAA8-1]
DR AlphaFoldDB; Q2TAA8; -.
DR SMR; Q2TAA8; -.
DR BioGRID; 120925; 24.
DR IntAct; Q2TAA8; 12.
DR MINT; Q2TAA8; -.
DR STRING; 9606.ENSP00000457241; -.
DR iPTMnet; Q2TAA8; -.
DR PhosphoSitePlus; Q2TAA8; -.
DR BioMuta; TSNAXIP1; -.
DR DMDM; 121946829; -.
DR jPOST; Q2TAA8; -.
DR MassIVE; Q2TAA8; -.
DR PaxDb; Q2TAA8; -.
DR PeptideAtlas; Q2TAA8; -.
DR PRIDE; Q2TAA8; -.
DR ProteomicsDB; 61455; -. [Q2TAA8-1]
DR ProteomicsDB; 61456; -. [Q2TAA8-2]
DR Antibodypedia; 29631; 31 antibodies from 15 providers.
DR DNASU; 55815; -.
DR Ensembl; ENST00000388833.7; ENSP00000373485.3; ENSG00000102904.15. [Q2TAA8-1]
DR GeneID; 55815; -.
DR KEGG; hsa:55815; -.
DR UCSC; uc002euj.5; human. [Q2TAA8-1]
DR CTD; 55815; -.
DR DisGeNET; 55815; -.
DR GeneCards; TSNAXIP1; -.
DR HGNC; HGNC:18586; TSNAXIP1.
DR HPA; ENSG00000102904; Tissue enhanced (fallopian tube, testis).
DR MIM; 607720; gene.
DR neXtProt; NX_Q2TAA8; -.
DR OpenTargets; ENSG00000102904; -.
DR PharmGKB; PA134961990; -.
DR VEuPathDB; HostDB:ENSG00000102904; -.
DR eggNOG; ENOG502QTWK; Eukaryota.
DR GeneTree; ENSGT00390000018598; -.
DR HOGENOM; CLU_028246_0_0_1; -.
DR InParanoid; Q2TAA8; -.
DR OrthoDB; 1123879at2759; -.
DR PhylomeDB; Q2TAA8; -.
DR TreeFam; TF329002; -.
DR PathwayCommons; Q2TAA8; -.
DR SignaLink; Q2TAA8; -.
DR BioGRID-ORCS; 55815; 18 hits in 1075 CRISPR screens.
DR ChiTaRS; TSNAXIP1; human.
DR GenomeRNAi; 55815; -.
DR Pharos; Q2TAA8; Tdark.
DR PRO; PR:Q2TAA8; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q2TAA8; protein.
DR Bgee; ENSG00000102904; Expressed in right uterine tube and 111 other tissues.
DR ExpressionAtlas; Q2TAA8; baseline and differential.
DR Genevisible; Q2TAA8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR032755; TSNAXIP1_N.
DR Pfam; PF15739; TSNAXIP1_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Developmental protein;
KW Differentiation; Reference proteome; Spermatogenesis.
FT CHAIN 1..658
FT /note="Translin-associated factor X-interacting protein 1"
FT /id="PRO_0000323608"
FT COILED 144..184
FT /evidence="ECO:0000255"
FT COILED 230..295
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..292
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_052710"
SQ SEQUENCE 658 AA; 76773 MW; 6CC03A9AB772AD01 CRC64;
MGGHLSPWPT YTSGQTILQN RKPCSDDYRK RVGSCQQHPF RTAKPQYLEE LENYLRKELL
LLDLGTDSTQ ELRLQPYREI FEFFIEDFKT YKPLLSSIKN AYEGMLAHQR EKIRALEPLK
AKLVTVNEDC NERILAMRAE EKYEISLLKK EKMNLLKLID KKNEEKISLQ SEVTKLRKNL
AEEYLHYLSE RDACKILIAD LNELRYQRED MSLAQSPGIW GEDPVKLTLA LKMTRQDLTR
TQMELNNMKA NFGDVVPRRD FEMQEKTNKD LQEQLDTLRA SYEEVRKEHE ILMQLHMSTL
KERDQFFSEL QEIQRTSTPR PDWTKCKDVV AGGPERWQML AEGKNSDQLV DVLLEEIGSG
LLREKDFFPG LGYGEAIPAF LRFDGLVENK KPSKKDVVNL LKDAWKERLA EEQKETFPDF
FFNFLEHRFG PSDAMAWAYT IFENIKIFHS NEVMSQFYAV LMGKRSENVY VTQKETVAQL
LKEMTNADSQ NEGLLTMEQF NTVLKSTFPL KTEEQIQELM EAGGWHPSSS NADLLNYRSL
FMEDEEGQSE PFVQKLWEQY MDEKDEYLQQ LKQELGIELH EEVTLPKLRG GLMTIDPSLD
KQTVNTYMSQ AFQLPESEMP EEGDEKEEAV VEILQTALER LQVIDIRRVG PREPEPAS
