ID   TXIP1_MOUSE             Reviewed;         704 AA.
AC   Q99P25; Q9DA98;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Translin-associated factor X-interacting protein 1;
DE            Short=Trax-interacting protein 1;
GN   Name=Tsnaxip1 {ECO:0000312|MGI:MGI:1919486}; Synonyms=Txi1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAK13524.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND INTERACTION WITH TSNAX.
RC   TISSUE=Testis {ECO:0000312|EMBL:AAK13524.1};
RX   PubMed=12036294; DOI=10.1006/geno.2002.6779;
RA   Bray J.D., Chennathukuzhi V.M., Hecht N.B.;
RT   "Identification and characterization of cDNAs encoding four novel proteins
RT   that interact with translin associated factor-X.";
RL   Genomics 79:799-808(2002).
RN   [2] {ECO:0000312|EMBL:BAB24380.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB24380.1};
RC   TISSUE=Testis {ECO:0000312|EMBL:BAB24380.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Possible role in spermatogenesis.
CC       {ECO:0000269|PubMed:12036294}.
CC   -!- SUBUNIT: Interacts with TSNAX. {ECO:0000269|PubMed:12036294}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:12036294}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testes. Predominantly
CC       detected in the post-meiotic stages of germ cells.
CC       {ECO:0000269|PubMed:12036294}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK13524.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF343750; AAK13524.1; ALT_INIT; mRNA.
DR   EMBL; AK006041; BAB24380.1; -; mRNA.
DR   CCDS; CCDS22614.1; -.
DR   RefSeq; NP_077765.1; NM_024445.4.
DR   AlphaFoldDB; Q99P25; -.
DR   BioGRID; 215241; 2.
DR   STRING; 10090.ENSMUSP00000034365; -.
DR   PhosphoSitePlus; Q99P25; -.
DR   EPD; Q99P25; -.
DR   PaxDb; Q99P25; -.
DR   PRIDE; Q99P25; -.
DR   ProteomicsDB; 298395; -.
DR   Antibodypedia; 29631; 31 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000034365; ENSMUSP00000034365; ENSMUSG00000031893.
DR   GeneID; 72236; -.
DR   KEGG; mmu:72236; -.
DR   UCSC; uc009nee.1; mouse.
DR   CTD; 55815; -.
DR   MGI; MGI:1919486; Tsnaxip1.
DR   VEuPathDB; HostDB:ENSMUSG00000031893; -.
DR   eggNOG; ENOG502QTWK; Eukaryota.
DR   GeneTree; ENSGT00390000018598; -.
DR   HOGENOM; CLU_028246_0_0_1; -.
DR   InParanoid; Q99P25; -.
DR   OMA; AKPRYLE; -.
DR   OrthoDB; 1123879at2759; -.
DR   PhylomeDB; Q99P25; -.
DR   TreeFam; TF329002; -.
DR   BioGRID-ORCS; 72236; 4 hits in 70 CRISPR screens.
DR   PRO; PR:Q99P25; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q99P25; protein.
DR   Bgee; ENSMUSG00000031893; Expressed in seminiferous tubule of testis and 57 other tissues.
DR   ExpressionAtlas; Q99P25; baseline and differential.
DR   Genevisible; Q99P25; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR032755; TSNAXIP1_N.
DR   Pfam; PF15739; TSNAXIP1_N; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Developmental protein; Differentiation;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..704
FT                   /note="Translin-associated factor X-interacting protein 1"
FT                   /id="PRO_0000323609"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          190..230
FT                   /evidence="ECO:0000255"
FT   COILED          304..342
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  81762 MW;  29423BA215DF2127 CRC64;
     MANLQERKSF SKPRISIQAS GGTPEAKGIE KRKLSQKRRT LPLQLSLGGH LSPWPTYTSG
     QTVLHNRKPC SDDSRNRANS CQQQSMSISK PKYLEQLENY LRKELLLLDL STDSAQELRL
     QPYREIFEFF IEDFKTYKPL LSSIKNAYEV MLAHQKERIR SLEPLKAKIV TMNEDCSERV
     LAMRAEERYE ISVLKKEKMN LLKLIDKKNE EKISLQSEVA KLRRSLAEEY LRYLTERDAR
     KILIGDLNEL RYQQEDMSLA QTPGVWGEDP VKLTLALKMT RQDLTRTQME LNTMKANSGD
     VVPRRDLEMQ EKTNMELQEQ LESLKADYEE VQKEHELLLQ LHMSTLKERD QFYNELQEIQ
     RTSTPRPDWT KCESIIAGGP ERWLVLAEGK NSDQLVDVLL EEIGMGLLRE KDFFPGLGFG
     DAIPPFLRFD GPVKNKKPSK KEVVNLLKDA WKERIAEEQK EPFPDFFFNF LERRFGVNDA
     MAWAYTIFEN IKLFRSSEIM NQFYAVLMGK NLESVYINQK KTLSHLLKEL LSVDTQNEGS
     ITMEQFSTIL KTTFPLKKEE QIQELMEAVG WGPDSSNTDM LNYRSLFNED EEGQSEPFVQ
     RLWEQYESDK EAYLEELKQE LDLDPLEDVT LLKMRGTLMN IDPTMDKQTL SAYLSQAYQI
     PAIDVPLEDE EKQGIISIKV ETALDRLRMA DTKRVGPREP DPAS