TXJ1_HETVE
ID TXJ1_HETVE Reviewed; 29 AA.
AC P61791;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Kappa-sparatoxin-Hv1e {ECO:0000305};
DE Short=Kappa-SPRTX-Hv1e {ECO:0000305};
DE AltName: Full=Toxin KJ1 {ECO:0000303|Ref.1};
OS Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Dionycha; Sparassidae; Heteropoda.
OX NCBI_TaxID=152925;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Venom;
RA Kelbaugh P.R., Saccomano N.A., Volkmann R.A.;
RT "Calcium channel blocking polypeptides from Heteropoda venatoria.";
RL Patent number US5627154, 06-MAY-1997.
CC -!- FUNCTION: Inhibitor of voltage-gated potassium channels of the Kv4/KCND
CC family (By similarity). Blocks calcium channels (Cav). {ECO:0000250,
CC ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC {ECO:0000250|UniProtKB:P58426}.
CC -!- MASS SPECTROMETRY: Mass=3273.18; Method=Electrospray;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 19 (HpTX2)
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P61791; -.
DR SMR; P61791; -.
DR ArachnoServer; AS000353; kappa-sparatoxin-Hv1e.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR011696; Huwentoxin-1.
DR Pfam; PF07740; Toxin_12; 1.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Knottin; Neurotoxin;
KW Potassium channel impairing toxin; Secreted; Toxin;
KW Voltage-gated calcium channel impairing toxin;
KW Voltage-gated potassium channel impairing toxin.
FT PEPTIDE 1..29
FT /note="Kappa-sparatoxin-Hv1e"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000044553"
FT DISULFID 3..17
FT /evidence="ECO:0000250|UniProtKB:P58426"
FT DISULFID 10..22
FT /evidence="ECO:0000250|UniProtKB:P58426"
FT DISULFID 16..26
FT /evidence="ECO:0000250|UniProtKB:P58426"
SQ SEQUENCE 29 AA; 3281 MW; 3E1BB9B695CFDA0A CRC64;
DDCGTLFSGC DTSKDCCEGY VCHLWCKYK