ID   TXL1_LASPA              Reviewed;          49 AA.
AC   P0CC18; P61505; Q5Q115;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=U1-theraphotoxin-Lp1a;
DE            Short=U1-TRTX-Lp1a;
DE   AltName: Full=Lasiotoxin-1;
DE            Short=LpTX1;
OS   Lasiodora parahybana (Brazilian salmon pink birdeater) (Brazilian salmon
OS   pink tarantula).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Lasiodora.
OX   NCBI_TaxID=268490;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RA   Escoubas P., Celerier M.-L., Romi-Lebrun R., Nakajima T.;
RT   "Two novel peptide neurotoxins from the venom of the tarantula Lasiodora
RT   parahybana.";
RL   Toxicon 35:805-806(1997).
RN   [2]
RP   REVIEW, AND DISULFIDE BONDS.
RX   PubMed=15066413; DOI=10.1016/j.toxicon.2004.02.007;
RA   Escoubas P., Rash L.;
RT   "Tarantulas: eight-legged pharmacists and combinatorial chemists.";
RL   Toxicon 43:555-574(2004).
CC   -!- FUNCTION: Is toxic to mice but not to insects. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=5722; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- MISCELLANEOUS: The primary structure of the mature peptide is identical
CC       to that of U1-theraphotoxin-Lsp1a (LTx1) from Lasiodora sp (AC P0CC19).
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 04
CC       (lasiotoxin) subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0CC18; -.
DR   ArachnoServer; AS000354; U1-theraphotoxin-Lp1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..49
FT                   /note="U1-theraphotoxin-Lp1a"
FT                   /id="PRO_0000087650"
FT   DISULFID        4..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        22..24
FT                   /evidence="ECO:0000305|PubMed:15066413"
FT   DISULFID        35..46
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   49 AA;  5731 MW;  3E2E527E349B0165 CRC64;
     FFECTFECDI KKEGKPCKPK GCKCKDKDNK DHKKCSGGWR CKLKLCLKF