TXL1_SCHPO
ID TXL1_SCHPO Reviewed; 290 AA.
AC Q9USR1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 144.
DE RecName: Full=Thioredoxin-like protein 1;
DE AltName: Full=Thioredoxin homolog 3;
GN Name=txl1; Synonyms=trx3; ORFNames=SPBC577.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=17668038; DOI=10.1139/w07-040;
RA Kim S.-J., Jung E.-M., Jung H.-J., Song Y.S., Park E.-H., Lim C.-J.;
RT "Cellular functions and transcriptional regulation of a third thioredoxin
RT from Schizosaccharomyces pombe.";
RL Can. J. Microbiol. 53:775-783(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17476701; DOI=10.1002/yea.1483;
RA Jimenez A., Mateos L., Pedrajas J.R., Miranda-Vizuete A., Revuelta J.L.;
RT "The txl1+ gene from Schizosaccharomyces pombe encodes a new thioredoxin-
RT like 1 protein that participates in the antioxidant defence against tert-
RT butyl hydroperoxide.";
RL Yeast 24:481-490(2007).
CC -!- FUNCTION: Has a role in cellular detoxification of alkyl hydroperoxide.
CC {ECO:0000269|PubMed:17476701, ECO:0000269|PubMed:17668038}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:17476701}. Nucleus {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:17476701}.
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DR EMBL; DQ386686; ABD47124.1; -; Genomic_DNA.
DR EMBL; CU329671; CAB54816.1; -; Genomic_DNA.
DR PIR; T40552; T40552.
DR RefSeq; NP_595306.1; NM_001021213.2.
DR AlphaFoldDB; Q9USR1; -.
DR SMR; Q9USR1; -.
DR BioGRID; 277543; 21.
DR STRING; 4896.SPBC577.08c.1; -.
DR iPTMnet; Q9USR1; -.
DR MaxQB; Q9USR1; -.
DR PaxDb; Q9USR1; -.
DR PRIDE; Q9USR1; -.
DR EnsemblFungi; SPBC577.08c.1; SPBC577.08c.1:pep; SPBC577.08c.
DR GeneID; 2541028; -.
DR KEGG; spo:SPBC577.08c; -.
DR PomBase; SPBC577.08c; txl1.
DR VEuPathDB; FungiDB:SPBC577.08c; -.
DR eggNOG; KOG0908; Eukaryota.
DR HOGENOM; CLU_072377_0_1_1; -.
DR InParanoid; Q9USR1; -.
DR OMA; CAPCVRI; -.
DR PhylomeDB; Q9USR1; -.
DR Reactome; R-SPO-9013420; RHOU GTPase cycle.
DR Reactome; R-SPO-9013424; RHOV GTPase cycle.
DR Reactome; R-SPO-9696273; RND1 GTPase cycle.
DR PRO; PR:Q9USR1; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0015035; F:protein-disulfide reductase activity; IDA:PomBase.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase activity; IMP:PomBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:PomBase.
DR Gene3D; 2.60.120.470; -; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR010400; PITH_dom.
DR InterPro; IPR037047; PITH_dom_sf.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF06201; PITH; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51532; PITH; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Cytoplasm; Disulfide bond; Electron transport; Nucleus;
KW Redox-active center; Reference proteome; Transport.
FT CHAIN 1..290
FT /note="Thioredoxin-like protein 1"
FT /id="PRO_0000372631"
FT DOMAIN 24..104
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT DOMAIN 118..290
FT /note="PITH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00864"
FT DISULFID 31..34
FT /note="Redox-active"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ SEQUENCE 290 AA; 31889 MW; 02C661616AEC2F2F CRC64;
MSVIEIRSYQ HWISTIPKSG YLAVDCYADW CGPCKAISPL FSQLASKYAS PKFVFAKVNV
DEQRQIASGL GVKAMPTFVF FENGKQIDML TGANPQALKE KVALISSKAT GTGALASSSS
APVKGFASLQ GCIENPQLEC LNQQDDHDLK SAFNSNPSSF LESDVDEQLM IYIPFLEVVK
VHSIAITPVK GETSSAPKTI KLYINQPNNL SFEDAESFTP TQVIEDIVYE QDDQPTIIPL
RFVKFQRVNS LVIFIYSNVG EEETTKISRL ELFGEPVGDS SKGKLQKVEA
