TXL2_LASPA
ID TXL2_LASPA Reviewed; 49 AA.
AC P61506;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=U1-theraphotoxin-Lp1b;
DE Short=U1-TRTX-Lp1b;
DE AltName: Full=Lasiotoxin-2;
DE Short=LpTX2;
OS Lasiodora parahybana (Brazilian salmon pink birdeater) (Brazilian salmon
OS pink tarantula).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Lasiodora.
OX NCBI_TaxID=268490;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Venom;
RA Escoubas P., Celerier M.-L., Romi-Lebrun R., Nakajima T.;
RT "Two novel peptide neurotoxins from the venom of the tarantula Lasiodora
RT parahybana.";
RL Toxicon 35:805-806(1997).
RN [2]
RP REVIEW, AND DISULFIDE BONDS.
RX PubMed=15066413; DOI=10.1016/j.toxicon.2004.02.007;
RA Escoubas P., Rash L.;
RT "Tarantulas: eight-legged pharmacists and combinatorial chemists.";
RL Toxicon 43:555-574(2004).
CC -!- FUNCTION: Is toxic to mice but not to insects. {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- MASS SPECTROMETRY: Mass=5674; Method=MALDI;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 04
CC (lasiotoxin) subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P61506; -.
DR ArachnoServer; AS000357; U1-theraphotoxin-Lp1b.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR012625; Toxin_20.
DR Pfam; PF08089; Toxin_20; 1.
DR PROSITE; PS60022; HWTX_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT CHAIN 1..49
FT /note="U1-theraphotoxin-Lp1b"
FT /id="PRO_0000087651"
FT DISULFID 4..17
FT /evidence="ECO:0000250"
FT DISULFID 8..41
FT /evidence="ECO:0000250"
FT DISULFID 22..24
FT /evidence="ECO:0000305|PubMed:15066413"
FT DISULFID 35..46
FT /evidence="ECO:0000250"
SQ SEQUENCE 49 AA; 5683 MW; 3B7E07761C398365 CRC64;
FFECTLECDI KKEGKPCKPK GCKCNDKDNK DHKKCSGGWR CKLKLCLKF