ID   TXLA4_CYRSC             Reviewed;          83 AA.
AC   B3FIS3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=U5-theraphotoxin-Hs1a 4;
DE            Short=U5-TRTX-Hs1a;
DE   AltName: Full=Lectin SHL-Ia4;
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18482741; DOI=10.1016/j.toxicon.2008.03.024;
RA   Jiang L., Peng L., Chen J., Zhang Y., Xiong X., Liang S.;
RT   "Molecular diversification based on analysis of expressed sequence tags
RT   from the venom glands of the Chinese bird spider Ornithoctonus huwena.";
RL   Toxicon 51:1479-1489(2008).
CC   -!- FUNCTION: Agglutinates erythrocytes. {ECO:0000250|UniProtKB:Q86C51}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8)
CC       subfamily. Hntx-8 sub-subfamily. {ECO:0000305}.
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DR   EMBL; EU195267; ABY77720.1; -; mRNA.
DR   AlphaFoldDB; B3FIS3; -.
DR   BMRB; B3FIS3; -.
DR   ArachnoServer; AS000355; U5-theraphotoxin-Hs1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   InterPro; IPR013140; Huwentoxin_CS1.
DR   Pfam; PF07740; Toxin_12; 1.
DR   PROSITE; PS60021; HWTX_1; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Lectin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000380168"
FT   CHAIN           50..81
FT                   /note="U5-theraphotoxin-Hs1a 4"
FT                   /id="PRO_0000380169"
FT   DISULFID        51..63
FT                   /evidence="ECO:0000250|UniProtKB:B3FIS6"
FT   DISULFID        56..68
FT                   /evidence="ECO:0000250|UniProtKB:B3FIS6"
FT   DISULFID        62..75
FT                   /evidence="ECO:0000250|UniProtKB:B3FIS6"
SQ   SEQUENCE   83 AA;  9437 MW;  3FA2FB357DE1CD68 CRC64;
     MKTSMFLTLT GLVLLFVDCY ASESEEKEFP KELLSSIFAA DSDFKVEERG CLGDKCDYNN
     GCCSGYVCSR TWKWCVLAGP WRR