ID   TXLA_SYNY3              Reviewed;         180 AA.
AC   P73920;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Thiol:disulfide interchange protein TxlA homolog;
GN   Name=txlA; OrderedLocusNames=sll1980;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Required for disulfide bond formation in some proteins. Acts
CC       by transferring its disulfide bond to other proteins and is reduced in
CC       the process (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA17986.1; -; Genomic_DNA.
DR   PIR; S75124; S75124.
DR   AlphaFoldDB; P73920; -.
DR   SMR; P73920; -.
DR   STRING; 1148.1653069; -.
DR   PaxDb; P73920; -.
DR   EnsemblBacteria; BAA17986; BAA17986; BAA17986.
DR   KEGG; syn:sll1980; -.
DR   eggNOG; COG0526; Bacteria.
DR   InParanoid; P73920; -.
DR   OMA; DNTKWLP; -.
DR   PhylomeDB; P73920; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016671; F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IBA:GO_Central.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   InterPro; IPR044241; TxlA/HCF164.
DR   PANTHER; PTHR47353; PTHR47353; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Membrane; Redox-active center;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..180
FT                   /note="Thiol:disulfide interchange protein TxlA homolog"
FT                   /id="PRO_0000120179"
FT   TRANSMEM        10..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..143
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        64..67
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   180 AA;  19517 MW;  F576D6D5D45D780C CRC64;
     MTPAKIRNAL LAVVAIALSA AVYLGFQTQT QGISLEAQAQ RAIPLATALD NGRPTLVEFY
     ADWCTSCQAM APDLAELKKN YGGSVNFAML NVDNNKWLPE VLRYRVDGIP HFVYLDDTGT
     AIAESIGEQP LRVLEQNITA LVAHEPIPYA NVTGQTSVVE NRTIEADPTS PRSHGNPRPS