ID   TXLB2_CYRSC             Reviewed;          83 AA.
AC   B3FIS7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=U5-theraphotoxin-Hs1b 2;
DE            Short=U5-TRTX-Hs1b;
DE   AltName: Full=Lectin SHL-Ib2;
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18482741; DOI=10.1016/j.toxicon.2008.03.024;
RA   Jiang L., Peng L., Chen J., Zhang Y., Xiong X., Liang S.;
RT   "Molecular diversification based on analysis of expressed sequence tags
RT   from the venom glands of the Chinese bird spider Ornithoctonus huwena.";
RL   Toxicon 51:1479-1489(2008).
CC   -!- FUNCTION: Agglutinates erythrocytes. {ECO:0000250|UniProtKB:Q86C51}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8)
CC       subfamily. Hntx-8 sub-subfamily. {ECO:0000305}.
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DR   EMBL; EU195271; ABY77724.1; -; mRNA.
DR   AlphaFoldDB; B3FIS7; -.
DR   PRIDE; B3FIS7; -.
DR   ArachnoServer; AS000698; U5-theraphotoxin-Hs1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   Pfam; PF07740; Toxin_12; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Lectin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000380176"
FT   CHAIN           50..81
FT                   /note="U5-theraphotoxin-Hs1b 2"
FT                   /id="PRO_0000380177"
FT   DISULFID        51..63
FT                   /evidence="ECO:0000250|UniProtKB:B3FIS6"
FT   DISULFID        56..68
FT                   /evidence="ECO:0000250|UniProtKB:B3FIS6"
FT   DISULFID        62..75
FT                   /evidence="ECO:0000250|UniProtKB:B3FIS6"
SQ   SEQUENCE   83 AA;  9477 MW;  986ED5EF154FA36D CRC64;
     MQTSMFLTLT GLVLLFVVCY ASESEEKEFP KELLSSIFAA DSDFKEEERG CFGYKCDYYK
     GCCSGYVCSP TWKWCVRPGP GRR