TXLNB_HUMAN
ID TXLNB_HUMAN Reviewed; 684 AA.
AC Q8N3L3; Q5HYH7; Q5VTF3; Q76L25; Q86T52; Q8N3S2;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Beta-taxilin;
DE AltName: Full=Muscle-derived protein 77;
DE Short=hMDP77;
GN Name=TXLNB; Synonyms=C6orf198, MDP77;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=15082161; DOI=10.1016/j.neulet.2004.02.058;
RA Itoh S., Uyeda A., Hukuoka Y., Fujimori K.E., Matsuda A., Ichinose S.,
RA Kobayashi H., Shinomiya K., Tanaka J., Taguchi T.;
RT "Muscle-specific protein MDP77 specifically promotes motor nerve
RT regeneration in rats.";
RL Neurosci. Lett. 360:175-177(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS MET-348 AND PRO-602.
RC TISSUE=Skeletal muscle;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS MET-348 AND PRO-602.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH STX1A; STX3A AND STX4A.
RX PubMed=15184072; DOI=10.1016/j.bbrc.2004.05.073;
RA Nogami S., Satoh S., Tanaka-Nakadate S., Yoshida K., Nakano M., Terano A.,
RA Shirataki H.;
RT "Identification and characterization of taxilin isoforms.";
RL Biochem. Biophys. Res. Commun. 319:936-943(2004).
CC -!- FUNCTION: Promotes motor nerve regeneration (By similarity). May be
CC involved in intracellular vesicle traffic. {ECO:0000250}.
CC -!- SUBUNIT: Binds to the C-terminal coiled coil region of syntaxin family
CC members STX1A, STX3A and STX4A. Has a preference for STX1A.
CC -!- INTERACTION:
CC Q8N3L3; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-6116822, EBI-4400025;
CC Q8N3L3; P20290: BTF3; NbExp=3; IntAct=EBI-6116822, EBI-1054687;
CC Q8N3L3; Q96K17: BTF3L4; NbExp=3; IntAct=EBI-6116822, EBI-6137496;
CC Q8N3L3; Q8TC20: CAGE1; NbExp=3; IntAct=EBI-6116822, EBI-10196469;
CC Q8N3L3; Q8NA61: CBY2; NbExp=3; IntAct=EBI-6116822, EBI-741724;
CC Q8N3L3; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-6116822, EBI-10961312;
CC Q8N3L3; Q49A88-3: CCDC14; NbExp=3; IntAct=EBI-6116822, EBI-12105646;
CC Q8N3L3; Q4G0S7: CCDC152; NbExp=3; IntAct=EBI-6116822, EBI-18398007;
CC Q8N3L3; A0A1B0GWI1: CCDC196; NbExp=6; IntAct=EBI-6116822, EBI-10181422;
CC Q8N3L3; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-6116822, EBI-347573;
CC Q8N3L3; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-6116822, EBI-10175300;
CC Q8N3L3; Q01850: CDR2; NbExp=3; IntAct=EBI-6116822, EBI-1181367;
CC Q8N3L3; Q96LK0: CEP19; NbExp=3; IntAct=EBI-6116822, EBI-741885;
CC Q8N3L3; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-6116822, EBI-11752486;
CC Q8N3L3; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-6116822, EBI-1104570;
CC Q8N3L3; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-6116822, EBI-10181988;
CC Q8N3L3; Q96MT8: CEP63; NbExp=3; IntAct=EBI-6116822, EBI-741977;
CC Q8N3L3; Q96MT8-3: CEP63; NbExp=3; IntAct=EBI-6116822, EBI-11522539;
CC Q8N3L3; Q8NHQ1: CEP70; NbExp=8; IntAct=EBI-6116822, EBI-739624;
CC Q8N3L3; Q96M91: CFAP53; NbExp=3; IntAct=EBI-6116822, EBI-742422;
CC Q8N3L3; Q8WUE5: CT55; NbExp=4; IntAct=EBI-6116822, EBI-6873363;
CC Q8N3L3; Q13561: DCTN2; NbExp=3; IntAct=EBI-6116822, EBI-715074;
CC Q8N3L3; Q05D60: DEUP1; NbExp=11; IntAct=EBI-6116822, EBI-748597;
CC Q8N3L3; Q9NPF5: DMAP1; NbExp=3; IntAct=EBI-6116822, EBI-399105;
CC Q8N3L3; Q96EV8: DTNBP1; NbExp=4; IntAct=EBI-6116822, EBI-465804;
CC Q8N3L3; Q8WWB3: DYDC1; NbExp=6; IntAct=EBI-6116822, EBI-740680;
CC Q8N3L3; O00471: EXOC5; NbExp=4; IntAct=EBI-6116822, EBI-949824;
CC Q8N3L3; Q3B820: FAM161A; NbExp=3; IntAct=EBI-6116822, EBI-719941;
CC Q8N3L3; Q96KS9: FAM167A; NbExp=3; IntAct=EBI-6116822, EBI-10290462;
CC Q8N3L3; O95995: GAS8; NbExp=3; IntAct=EBI-6116822, EBI-1052570;
CC Q8N3L3; Q08379: GOLGA2; NbExp=3; IntAct=EBI-6116822, EBI-618309;
CC Q8N3L3; Q68CZ6: HAUS3; NbExp=3; IntAct=EBI-6116822, EBI-2558217;
CC Q8N3L3; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-6116822, EBI-3437878;
CC Q8N3L3; P13646: KRT13; NbExp=3; IntAct=EBI-6116822, EBI-1223876;
CC Q8N3L3; P19012: KRT15; NbExp=6; IntAct=EBI-6116822, EBI-739566;
CC Q8N3L3; P08779: KRT16; NbExp=3; IntAct=EBI-6116822, EBI-356410;
CC Q8N3L3; Q7Z3Y9: KRT26; NbExp=3; IntAct=EBI-6116822, EBI-12084444;
CC Q8N3L3; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-6116822, EBI-3044087;
CC Q8N3L3; O76011: KRT34; NbExp=3; IntAct=EBI-6116822, EBI-1047093;
CC Q8N3L3; Q92764: KRT35; NbExp=3; IntAct=EBI-6116822, EBI-1058674;
CC Q8N3L3; O76014: KRT37; NbExp=3; IntAct=EBI-6116822, EBI-1045716;
CC Q8N3L3; O76015: KRT38; NbExp=9; IntAct=EBI-6116822, EBI-1047263;
CC Q8N3L3; Q6A163: KRT39; NbExp=3; IntAct=EBI-6116822, EBI-11958242;
CC Q8N3L3; P02538: KRT6A; NbExp=3; IntAct=EBI-6116822, EBI-702198;
CC Q8N3L3; O95678: KRT75; NbExp=3; IntAct=EBI-6116822, EBI-2949715;
CC Q8N3L3; Q8IYD9: LAS2; NbExp=3; IntAct=EBI-6116822, EBI-749878;
CC Q8N3L3; O60711: LPXN; NbExp=3; IntAct=EBI-6116822, EBI-744222;
CC Q8N3L3; Q96LR2: LURAP1; NbExp=7; IntAct=EBI-6116822, EBI-741355;
CC Q8N3L3; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-6116822, EBI-1216080;
CC Q8N3L3; Q9NS73: MBIP; NbExp=4; IntAct=EBI-6116822, EBI-741953;
CC Q8N3L3; Q9NS73-5: MBIP; NbExp=3; IntAct=EBI-6116822, EBI-10182361;
CC Q8N3L3; Q9NPJ6: MED4; NbExp=4; IntAct=EBI-6116822, EBI-394607;
CC Q8N3L3; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-6116822, EBI-16439278;
CC Q8N3L3; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-6116822, EBI-743811;
CC Q8N3L3; I6L9F6: NEFL; NbExp=3; IntAct=EBI-6116822, EBI-10178578;
CC Q8N3L3; P35240-4: NF2; NbExp=3; IntAct=EBI-6116822, EBI-1014514;
CC Q8N3L3; Q13287: NMI; NbExp=9; IntAct=EBI-6116822, EBI-372942;
CC Q8N3L3; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-6116822, EBI-8466445;
CC Q8N3L3; A5D8V7-2: ODAD3; NbExp=3; IntAct=EBI-6116822, EBI-10173824;
CC Q8N3L3; Q9BRV8: SIKE1; NbExp=3; IntAct=EBI-6116822, EBI-1773646;
CC Q8N3L3; O75971-2: SNAPC5; NbExp=3; IntAct=EBI-6116822, EBI-12004298;
CC Q8N3L3; Q9UN79: SOX13; NbExp=3; IntAct=EBI-6116822, EBI-3928516;
CC Q8N3L3; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-6116822, EBI-725557;
CC Q8N3L3; O75528: TADA3; NbExp=3; IntAct=EBI-6116822, EBI-473249;
CC Q8N3L3; P56279: TCL1A; NbExp=3; IntAct=EBI-6116822, EBI-749995;
CC Q8N3L3; P40222: TXLNA; NbExp=11; IntAct=EBI-6116822, EBI-359793;
CC Q8N3L3; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-6116822, EBI-10180829;
CC Q8N3L3; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-6116822, EBI-739895;
CC Q8N3L3; Q9BVJ6: UTP14A; NbExp=3; IntAct=EBI-6116822, EBI-473284;
CC Q8N3L3; P08670: VIM; NbExp=6; IntAct=EBI-6116822, EBI-353844;
CC Q8N3L3; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-6116822, EBI-2799833;
CC Q8N3L3; Q9Y3C0: WASHC3; NbExp=4; IntAct=EBI-6116822, EBI-712969;
CC Q8N3L3; P17024: ZNF20; NbExp=3; IntAct=EBI-6116822, EBI-717634;
CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle.
CC -!- SIMILARITY: Belongs to the taxilin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD38924.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAD91140.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB085905; BAC92688.1; -; mRNA.
DR EMBL; AL832322; CAD38617.1; -; mRNA.
DR EMBL; AL834248; CAD38924.2; ALT_INIT; mRNA.
DR EMBL; AL831988; CAD91140.1; ALT_INIT; mRNA.
DR EMBL; BX647633; CAI45978.1; -; mRNA.
DR EMBL; AL592434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL158850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115383; AAI15384.1; -; mRNA.
DR EMBL; BC115384; AAI15385.1; -; mRNA.
DR CCDS; CCDS34545.1; -.
DR RefSeq; NP_694967.3; NM_153235.3.
DR RefSeq; XP_005266893.1; XM_005266836.1.
DR RefSeq; XP_011533807.1; XM_011535505.2.
DR RefSeq; XP_016865811.1; XM_017010322.1.
DR AlphaFoldDB; Q8N3L3; -.
DR SMR; Q8N3L3; -.
DR BioGRID; 127952; 90.
DR IntAct; Q8N3L3; 81.
DR STRING; 9606.ENSP00000351206; -.
DR iPTMnet; Q8N3L3; -.
DR PhosphoSitePlus; Q8N3L3; -.
DR BioMuta; TXLNB; -.
DR DMDM; 55583953; -.
DR jPOST; Q8N3L3; -.
DR MassIVE; Q8N3L3; -.
DR MaxQB; Q8N3L3; -.
DR PaxDb; Q8N3L3; -.
DR PeptideAtlas; Q8N3L3; -.
DR PRIDE; Q8N3L3; -.
DR ProteomicsDB; 71819; -.
DR Antibodypedia; 33084; 131 antibodies from 18 providers.
DR DNASU; 167838; -.
DR Ensembl; ENST00000358430.8; ENSP00000351206.3; ENSG00000164440.15.
DR GeneID; 167838; -.
DR KEGG; hsa:167838; -.
DR MANE-Select; ENST00000358430.8; ENSP00000351206.3; NM_153235.4; NP_694967.3.
DR UCSC; uc063rxd.1; human.
DR CTD; 167838; -.
DR GeneCards; TXLNB; -.
DR HGNC; HGNC:21617; TXLNB.
DR HPA; ENSG00000164440; Group enriched (heart muscle, skeletal muscle, tongue).
DR MIM; 611438; gene.
DR neXtProt; NX_Q8N3L3; -.
DR OpenTargets; ENSG00000164440; -.
DR PharmGKB; PA134878600; -.
DR VEuPathDB; HostDB:ENSG00000164440; -.
DR eggNOG; KOG1850; Eukaryota.
DR GeneTree; ENSGT00940000157418; -.
DR HOGENOM; CLU_025501_2_0_1; -.
DR InParanoid; Q8N3L3; -.
DR OMA; FMIIHHP; -.
DR OrthoDB; 904532at2759; -.
DR PhylomeDB; Q8N3L3; -.
DR TreeFam; TF318595; -.
DR PathwayCommons; Q8N3L3; -.
DR SignaLink; Q8N3L3; -.
DR BioGRID-ORCS; 167838; 9 hits in 1064 CRISPR screens.
DR ChiTaRS; TXLNB; human.
DR GeneWiki; TXLNB; -.
DR GenomeRNAi; 167838; -.
DR Pharos; Q8N3L3; Tbio.
DR PRO; PR:Q8N3L3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8N3L3; protein.
DR Bgee; ENSG00000164440; Expressed in vastus lateralis and 124 other tissues.
DR ExpressionAtlas; Q8N3L3; baseline and differential.
DR Genevisible; Q8N3L3; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR GO; GO:0019905; F:syntaxin binding; IEA:InterPro.
DR InterPro; IPR026183; Taxilin_fam.
DR PANTHER; PTHR16127; PTHR16127; 1.
DR Pfam; PF09728; Taxilin; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..684
FT /note="Beta-taxilin"
FT /id="PRO_0000189423"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..351
FT /evidence="ECO:0000255"
FT COILED 378..467
FT /evidence="ECO:0000255"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 474
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VBT1"
FT MOD_RES 483
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VBT1"
FT VARIANT 11
FT /note="A -> T (in dbSNP:rs9321712)"
FT /id="VAR_019807"
FT VARIANT 348
FT /note="V -> M (in dbSNP:rs17068451)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_057729"
FT VARIANT 527
FT /note="I -> T (in dbSNP:rs9495392)"
FT /id="VAR_057730"
FT VARIANT 602
FT /note="A -> P (in dbSNP:rs9495391)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_057731"
FT CONFLICT 270
FT /note="K -> E (in Ref. 2; CAD38617)"
FT /evidence="ECO:0000305"
FT CONFLICT 597
FT /note="A -> T (in Ref. 2; CAD91140)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 684 AA; 76519 MW; 5C40DF4B3085C590 CRC64;
MEANHSEQLS AERQSTPPGD SSSLPSHNGL EKEDGQDSPT PVQPPEKEAS VHPDISEELN
RQLEDIINTY GSAASTAGKE GSARASEQPE NAESPDNEDG DCEETTEEAG REPVASGEPP
TVKEPVSNKE QKLEKKILKG LGKEANLLMQ NLNKLQTPEE KFDFLFKKYA ELLDEHRTEQ
KKLKLLQKKQ VQIQKEKDQL QGEHSRAILA RSKLESLCRE LQRHNKTLKE EALQRAREEE
EKRKEITSHF QSTLTDIQGQ IEQQSERNMK LCQENTELAE KLKSIIDQYE LREEHLDKIF
KHRELQQKLV DAKLEQAQEM MKEAEERHKR EKEYLLNQAA EWKLQAKVLK EQETVLQAQL
TLYSGRFEEF QSTLTKSNEV FATFKQEMDK TTKKMKKLEK DTATWKARFE NCNKALLDMI
EEKALRAKEY ECFVMKIGRL ENLCRALQEE RNELHKKIRD AEISEKDDQS QHNSDEEPES
NVSVDQEIDA EEVNSVQTAV KNLATAFMII HHPESTPHQS KETQPEIGSS QESADAALKE
PEQPPLIPSR DSESPLPPLT PQAEAEGGSD AEPPSKASNS PAGLGAETQC EGLPVGAQAD
QASWKPEAEA SGQAPQAPTE ASLQKMEADV PAPACAAEEH VAAMVPACEP SRQPPRAAAE
ELPVGASAGP QPRNVADTNL EGVD
