TXLNB_MOUSE
ID TXLNB_MOUSE Reviewed; 685 AA.
AC Q8VBT1; B2RU93; Q3UVB8; Q8BUK2;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Beta-taxilin;
DE AltName: Full=Muscle-derived protein 77;
GN Name=Txlnb; Synonyms=Mdp77;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=11805063; DOI=10.1093/genetics/160.1.279;
RA Benson K.F., Chada K.;
RT "Molecular characterization of the mouse In(10)17Rk inversion and
RT identification of a novel muscle-specific gene at the proximal
RT breakpoint.";
RL Genetics 160:279-287(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, and Embryonic heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477; SER-484 AND SER-486, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Promotes motor nerve regeneration. May be involved in
CC intracellular vesicle traffic (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds to the C-terminal coiled coil region of syntaxin family
CC members STX1A, STX3A and STX4A. Has a preference for STX1A (By
CC similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in skeletal muscle.
CC {ECO:0000269|PubMed:11805063}.
CC -!- SIMILARITY: Belongs to the taxilin family. {ECO:0000305}.
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DR EMBL; AF422244; AAL33909.1; -; mRNA.
DR EMBL; AF422245; AAL33910.1; -; mRNA.
DR EMBL; AK084639; BAC39238.2; -; mRNA.
DR EMBL; AK137442; BAE23352.1; -; mRNA.
DR EMBL; BC141023; AAI41024.1; -; mRNA.
DR CCDS; CCDS35851.1; -.
DR RefSeq; NP_619534.2; NM_138628.3.
DR AlphaFoldDB; Q8VBT1; -.
DR SMR; Q8VBT1; -.
DR BioGRID; 237544; 6.
DR IntAct; Q8VBT1; 2.
DR MINT; Q8VBT1; -.
DR STRING; 10090.ENSMUSP00000044936; -.
DR iPTMnet; Q8VBT1; -.
DR PhosphoSitePlus; Q8VBT1; -.
DR MaxQB; Q8VBT1; -.
DR PaxDb; Q8VBT1; -.
DR PeptideAtlas; Q8VBT1; -.
DR PRIDE; Q8VBT1; -.
DR ProteomicsDB; 297759; -.
DR Antibodypedia; 33084; 131 antibodies from 18 providers.
DR Ensembl; ENSMUST00000037964; ENSMUSP00000044936; ENSMUSG00000039891.
DR GeneID; 378431; -.
DR KEGG; mmu:378431; -.
DR UCSC; uc007elv.1; mouse.
DR CTD; 167838; -.
DR MGI; MGI:2671945; Txlnb.
DR VEuPathDB; HostDB:ENSMUSG00000039891; -.
DR eggNOG; KOG1850; Eukaryota.
DR GeneTree; ENSGT00940000157418; -.
DR HOGENOM; CLU_025501_2_0_1; -.
DR InParanoid; Q8VBT1; -.
DR OMA; FMIIHHP; -.
DR OrthoDB; 904532at2759; -.
DR PhylomeDB; Q8VBT1; -.
DR TreeFam; TF318595; -.
DR BioGRID-ORCS; 378431; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Txlnb; mouse.
DR PRO; PR:Q8VBT1; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8VBT1; protein.
DR Bgee; ENSMUSG00000039891; Expressed in interventricular septum and 105 other tissues.
DR Genevisible; Q8VBT1; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0019905; F:syntaxin binding; IEA:InterPro.
DR InterPro; IPR026183; Taxilin_fam.
DR PANTHER; PTHR16127; PTHR16127; 1.
DR Pfam; PF09728; Taxilin; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..685
FT /note="Beta-taxilin"
FT /id="PRO_0000189424"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 138..354
FT /evidence="ECO:0000255"
FT COILED 381..470
FT /evidence="ECO:0000255"
FT COMPBIAS 14..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..114
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 477
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 484
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 486
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 80..85
FT /note="RGKEST -> EEGDA (in Ref. 1; AAL33909)"
FT /evidence="ECO:0000305"
FT CONFLICT 313..314
FT /note="VD -> AY (in Ref. 2; BAC39238)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 685 AA; 77207 MW; 4EC5F4F2EAE03895 CRC64;
MEINHPDQLS VEHPTPPGDS SSLNQNGPGK QDGERCSTSG QAPEQEGSLH PEKGAHDVAE
ELSRQLEDII STYGSAASPR GKESTSETKE QPPNTEAPDN EDVDYEETTE EIDREPTAPE
EPAAAKEPVS NKEQKLEKKI LKGLGKEANL LMQNLNKLQA PEEKLDFLFK KYTELLDEHR
TEQKKLKLLL KQQAQTQREK DQLQSEHNRA VLARSKLESL CRELQRHNKT LKEETLQRAR
EEEEKRKEIT SHFQTTLTDI QTQIEQQSER NMKLCQENTE LAEKLKSIID QYELREEHLD
KIFKHRELQQ KLVDAKLEEA QELMQEAEER HRREKEYLLN QAAEWKLQAK VLKEQETVLQ
AQLTLYSGRF EEFQSTLTKS NEVFATFKQE MDKTTKKMKK LEKDTATWKA RFENCNKALL
DMIEEKALRA KEYECFVMKI QRLENLCRAL QEERKELYKK IREAKMSEKE DQVQRTSEEE
PEPSVSENEE VDAEEANSFQ KAVENLATAF TILHHPEFTP DQPTERQLAV NGPQSGSDVT
HQHPETARLN HPSLPADSGS PRPPVGAQAV AEGVCEATPA PTASCTPAEA ELQSQGLPAE
NTPGPKPHKP EANTSGQAPL SPAQGSLSVV EAKYDISPSP ESEGDSAVVP GCESREQPPP
EVTDIPVGPS TGLPREPDAC LNGVD
