ID   TXLS2_PSETR             Reviewed;          33 AA.
AC   P0DSL8;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=U1-pseudomyrmecitoxin-Pt1 subunit LS2 {ECO:0000305};
DE            Short=U1-PSDTX-Pt1 subunit LS2 {ECO:0000305};
DE   AltName: Full=Myrmexin I subunit LS2/Myrmexin III subunit LS2/Myrmexin IV subunit LS2 {ECO:0000303|PubMed:10758275};
DE   AltName: Full=U1-pseudomyrmecitoxin-Pt1a subunit LS2/U1-pseudomyrmecitoxin-Pt1c subunit LS2/U1-pseudomyrmecitoxin-Pt1d subunit LS2 {ECO:0000303|PubMed:26805882};
DE            Short=U1-PSDTX-Pt1a subunit LS2/U1-PSDTX-Pt1c subunit LS2/U1-PSDTX-Pt1d subunit LS2 {ECO:0000303|PubMed:26805882};
OS   Pseudomyrmex triplarinus (Ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Pseudomyrmecinae; Pseudomyrmex.
OX   NCBI_TaxID=600763;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=10758275; DOI=10.1016/s0041-0101(99)00233-0;
RA   Pan J., Hink W.F.;
RT   "Isolation and characterization of myrmexins, six isoforms of venom
RT   proteins with anti-inflammatory activity from the tropical ant,
RT   Pseudomyrmex triplarinus.";
RL   Toxicon 38:1403-1413(2000).
RN   [2]
RP   REVIEW, AND NOMENCLATURE.
RX   PubMed=26805882; DOI=10.3390/toxins8010030;
RA   Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M.,
RA   Dejean A.;
RT   "The biochemical toxin arsenal from ant venoms.";
RL   Toxins 8:1-28(2016).
CC   -!- FUNCTION: This heterodimer may have anti-inflammatory properties, since
CC       the myrmexin complex (composed of 6 SS-LS heterodimers) inhibits
CC       carrageenin-induced edema in a dose-dependent manner (after
CC       subcutaneous injection into rats). {ECO:0000269|PubMed:10758275}.
CC   -!- SUBUNIT: Heterodimer composed of subunit LS2 and subunit SS1,
CC       heterodimer composed of subunit LS2 and SS2, and heterodimer composed
CC       of subunit LS2 and SS3; disulfide-linked.
CC       {ECO:0000269|PubMed:10758275}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10758275}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:10758275}.
CC   -!- MISCELLANEOUS: There are 6 heterodimeric myrmexins which consist of a
CC       small subunit (SS1 or SS2 or SS3) disulfide-linked to a larger, quite
CC       structurally unrelated subunit (LS1 or LS2).
CC       {ECO:0000305|PubMed:10758275}.
CC   -!- MISCELLANEOUS: MALDI experiments give a mass of 7069 Da for U1-PSDTX-
CC       Pt1a heterodimer (SS1+LS2). {ECO:0000269|PubMed:10758275}.
CC   -!- MISCELLANEOUS: MALDI experiments give a mass of 7090 Da for U1-PSDTX-
CC       Pt1c heterodimer (SS2+LS2). {ECO:0000269|PubMed:10758275}.
CC   -!- MISCELLANEOUS: MALDI experiments give a mass of 7143 Da for U1-PSDTX-
CC       Pt1d heterodimer (SS3+LS2). {ECO:0000269|PubMed:10758275}.
CC   -!- SIMILARITY: Belongs to the myrmexin family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DSL8; -.
DR   SMR; P0DSL8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..33
FT                   /note="U1-pseudomyrmecitoxin-Pt1 subunit LS2"
FT                   /id="PRO_0000447113"
FT   DISULFID        21
FT                   /note="Interchain (with C-17 in SS1 or SS2 or SS3)"
FT                   /evidence="ECO:0000305"
FT   DISULFID        31
FT                   /note="Interchain (with C-26 in SS1 or SS2 or SS3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   33 AA;  3608 MW;  02862AB22DD4F6F6 CRC64;
     ISLAQIKKLL QIIKQGLKAI CDNRDLIAKG CQA