ID   TXLT2_LASSB             Reviewed;          99 AA.
AC   Q5Q114;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=U1-theraphotoxin-Lsp1b;
DE            Short=U1-TRTX-Lsp1b;
DE   AltName: Full=LTx2;
DE   Flags: Precursor;
OS   Lasiodora sp. (strain IBSP 8539) (Brazilian salmon pink birdeater)
OS   (Brazilian salmon pink tarantula).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Lasiodora; unclassified Lasiodora.
OX   NCBI_TaxID=300858;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=15530979; DOI=10.1016/j.toxicon.2004.08.004;
RA   Vieira A.L.G., Moura M.B., Baba E.H., Chavez-Olortegui C., Kalapothakis E.,
RA   Castro I.M.;
RT   "Molecular cloning of toxins expressed by the venom gland of Lasiodora
RT   sp.";
RL   Toxicon 44:949-952(2004).
CC   -!- FUNCTION: Is toxic to mice but not to insects. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 04
CC       (lasiotoxin) subfamily. {ECO:0000305}.
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DR   EMBL; AY794220; AAV68327.1; -; mRNA.
DR   AlphaFoldDB; Q5Q114; -.
DR   SMR; Q5Q114; -.
DR   ArachnoServer; AS000357; U1-theraphotoxin-Lp1b.
DR   ArachnoServer; AS000610; U1-theraphotoxin-Lsp1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..50
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000287392"
FT   CHAIN           51..99
FT                   /note="U1-theraphotoxin-Lsp1b"
FT                   /id="PRO_0000287393"
FT   DISULFID        54..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..91
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..74
FT                   /evidence="ECO:0000305"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11072 MW;  715C87BBA82159E9 CRC64;
     MRSLTLAALL LCSLLLVFHT SAAEELQAQE GHLMIPGDTD TALETVDDER LFECTFECDI
     KKEGKPCKPK GCKCDDKDNK DHKKCSGGWR CKLKLCLKI