ID   TXLT4_LASSB             Reviewed;          99 AA.
AC   A3F7X1;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=U2-theraphotoxin-Lsp1a;
DE            Short=U2-TRTX-Lsp1a;
DE   AltName: Full=LTx4 {ECO:0000312|EMBL:ABN13623.1};
DE   Flags: Precursor;
OS   Lasiodora sp. (strain IBSP 8539) (Brazilian salmon pink birdeater)
OS   (Brazilian salmon pink tarantula).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Lasiodora; unclassified Lasiodora.
OX   NCBI_TaxID=300858;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Castro I.M., Moura M.B., Kalapothakis E.;
RT   "Screening of a Lasiodora sp. expression library and molecular cloning of
RT   Lasiodora sp. toxins in expression vectors.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Insecticidal neurotoxin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 08 (Ltx-4)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EF219061; ABN13623.1; -; mRNA.
DR   AlphaFoldDB; A3F7X1; -.
DR   ArachnoServer; AS000509; U2-theraphotoxin-Lsp1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012627; Toxin_22.
DR   Pfam; PF08092; Toxin_22; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..57
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000290256"
FT   CHAIN           58..99
FT                   /note="U2-theraphotoxin-Lsp1a"
FT                   /id="PRO_0000290257"
FT   DISULFID        58..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..93
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11251 MW;  F01E8C8F127CAC18 CRC64;
     MNTIQVIIFA VVLVLTVTVG QADEDSPEAS LLRKLKEAEA SLFGQNLEES RNSRQKRCGG
     VDAPCDKDRP DCCSYAECLR PSGYGWWHGT YYCYRKRER