ID   TXM15_MACGS             Reviewed;          65 AA.
AC   P0C2V1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=U15-hexatoxin-Mg1a;
DE            Short=U15-HXTX-Mg1a;
DE   AltName: Full=Neurotoxin magi-15;
OS   Macrothele gigas (Japanese funnel web spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Macrothelidae; Macrothele.
OX   NCBI_TaxID=223896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=15246762; DOI=10.1016/j.toxicon.2004.05.012;
RA   Satake H., Villegas E., Oshiro N., Terada K., Shinada T., Corzo G.;
RT   "Rapid and efficient identification of cysteine-rich peptides by random
RT   screening of a venom gland cDNA library from the hexathelid spider
RT   Macrothele gigas.";
RL   Toxicon 44:149-156(2004).
CC   -!- FUNCTION: Intrathorax injection into crickets causes paralysis
CC       prolonged for more than 60 min, followed by recovery.
CC       {ECO:0000269|PubMed:15246762}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=6942.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15246762};
CC   -!- SIMILARITY: Belongs to the neurotoxin 25 family. F7 subfamily.
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DR   AlphaFoldDB; P0C2V1; -.
DR   ArachnoServer; AS000368; U15-hexatoxin-Mg1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..65
FT                   /note="U15-hexatoxin-Mg1a"
FT                   /id="PRO_0000285715"
SQ   SEQUENCE   65 AA;  6951 MW;  BAC9E1B8F068AA3A CRC64;
     ECSKQLGESC KCNKQCCGAT VICGTIYVGG KEENLCIEKT SNNAILNFFG KIAHVVENGL
     SFSCD