TXM3A_DINQU
ID TXM3A_DINQU Reviewed; 66 AA.
AC P0DSK0;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 08-MAY-2019, sequence version 1.
DT 25-MAY-2022, entry version 10.
DE RecName: Full=M-poneratoxin-Dq3a {ECO:0000303|PubMed:28976889};
DE Short=M-PONTX-Dq3a {ECO:0000303|PubMed:28976889};
DE AltName: Full=Dinoponeratoxin {ECO:0000303|PubMed:28976889};
DE Short=DnTx {ECO:0000303|PubMed:28976889};
DE AltName: Full=Peptide sDq-2561 {ECO:0000303|PubMed:28976889};
DE AltName: Full=U-poneritoxin(01)-Dq6a {ECO:0000305};
DE Short=PONTX(01)-Dq6 {ECO:0000303|PubMed:30214940};
DE Short=U-PONTX(01)-Dq6a {ECO:0000305};
DE Contains:
DE RecName: Full=M-poneratoxin-Dq3b {ECO:0000303|PubMed:28976889};
DE Short=M-PONTX-Dq3b {ECO:0000303|PubMed:28976889};
DE AltName: Full=Peptide sDq-1503 {ECO:0000303|PubMed:28976889};
DE Contains:
DE RecName: Full=M-poneratoxin-Dq3c {ECO:0000303|PubMed:28976889};
DE Short=M-PONTX-Dq3c {ECO:0000303|PubMed:28976889};
DE AltName: Full=Peptide sDq-1319 {ECO:0000303|PubMed:28976889};
DE Flags: Precursor;
OS Dinoponera quadriceps (South American ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Dinoponera.
OX NCBI_TaxID=609295;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=24498135; DOI=10.1371/journal.pone.0087556;
RA Torres A.F., Huang C., Chong C.M., Leung S.W., Prieto-da-Silva A.R.,
RA Havt A., Quinet Y.P., Martins A.M., Lee S.M., Radis-Baptista G.;
RT "Transcriptome analysis in venom gland of the predatory giant ant
RT Dinoponera quadriceps: insights into the polypeptide toxin arsenal of
RT hymenopterans.";
RL PLoS ONE 9:E87556-E87556(2014).
RN [2]
RP FUNCTION, SYNTHESIS OF 44-54; 44-56 AND 44-66, AND PHARMACEUTICAL.
RX PubMed=28976889; DOI=10.1515/hsz-2017-0198;
RA Lima D.B., Mello C.P., Bandeira I.C.J., Pessoa Bezerra de Menezes R.R.P.,
RA Sampaio T.L., Falcao C.B., Morlighem J.R.L., Radis-Baptista G.,
RA Martins A.M.C.;
RT "The dinoponeratoxin peptides from the giant ant Dinoponera quadriceps
RT display in vitro antitrypanosomal activity.";
RL Biol. Chem. 399:187-196(2018).
RN [3]
RP NOMENCLATURE.
RX PubMed=30214940; DOI=10.1126/sciadv.aau4640;
RA Robinson S.D., Mueller A., Clayton D., Starobova H., Hamilton B.R.,
RA Payne R.J., Vetter I., King G.F., Undheim E.A.B.;
RT "A comprehensive portrait of the venom of the giant red bull ant, Myrmecia
RT gulosa, reveals a hyperdiverse hymenopteran toxin gene family.";
RL Sci. Adv. 4:EAAU4640-EAAU4640(2018).
CC -!- FUNCTION: [M-poneratoxin-Dq3a]: May have antimicrobial properties, like
CC most ant linear peptides (Probable). In addition, when tested in vitro
CC on the parasite Trypanosoma cruzi (responsible of the Chagas disease),
CC is able to potently reduce the number of the three forms (epimastigote,
CC trypomastigote and amastigote) by inducing cell death through necrosis
CC (PubMed:28976889). {ECO:0000269|PubMed:28976889, ECO:0000305}.
CC -!- FUNCTION: [M-poneratoxin-Dq3b]: May have antimicrobial properties, like
CC most ant linear peptides (Probable). In addition, when tested in vitro
CC on the parasite Trypanosoma cruzi (responsible of the Chagas disease),
CC is able to moderately reduce the number of the forms epimastigote and
CC trypomastigote. Its activity on the amastigote form has not been tested
CC (PubMed:28976889). {ECO:0000269|PubMed:28976889, ECO:0000305}.
CC -!- FUNCTION: [M-poneratoxin-Dq3c]: May have antimicrobial properties, like
CC most ant linear peptides (Probable). In addition, when tested in vitro
CC on the parasite Trypanosoma cruzi (responsible of the Chagas disease),
CC shows only a weak reduction of the number of the trypomastigote forms.
CC Has no activity on the epimastigote forms. Its activity on the
CC amastigote form has not been tested (PubMed:28976889).
CC {ECO:0000269|PubMed:28976889, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24498135}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:24498135}.
CC -!- PHARMACEUTICAL: [M-poneratoxin-Dq3a]: Promising drug candidate or lead
CC for the development of new drugs to treat Chagas disease (also called
CC American Trypanosomiasis). Shows a high selectivity index (SI) of 80 to
CC the trypomastigote forms. {ECO:0000305|PubMed:28976889}.
CC -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC superfamily. Medium-length antimicrobial peptide (group 3) family.
CC Ponericin-W subfamily. {ECO:0000305}.
CC -!- CAUTION: It is not indicated if M-poneratoxin-Dq3b and M-poneratoxin-
CC Dq3c have been predicted from the transcriptome or found as mature
CC peptides in the peptidome. Authors indicate they have been cleaved from
CC M-poneratoxin-Dq3a and amidated. {ECO:0000305|PubMed:28976889}.
CC -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC (NCBI);
CC URL="https://www.ncbi.nlm.nih.gov/nuccore/GANS01000001";
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DR AlphaFoldDB; P0DSK0; -.
DR Proteomes; UP000515204; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0098542; P:defense response to other organism; IEA:InterPro.
DR InterPro; IPR012523; Antimicrobial_4.
DR Pfam; PF08024; Antimicrobial_4; 1.
PE 3: Inferred from homology;
KW Antimicrobial; Pharmaceutical; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..43
FT /evidence="ECO:0000305|PubMed:24498135"
FT /id="PRO_0000447082"
FT PEPTIDE 44..66
FT /note="M-poneratoxin-Dq3a"
FT /evidence="ECO:0000305|PubMed:24498135"
FT /id="PRO_0000447083"
FT PEPTIDE 44..56
FT /note="M-poneratoxin-Dq3b"
FT /evidence="ECO:0000305|PubMed:28976889"
FT /id="PRO_0000451099"
FT PEPTIDE 44..54
FT /note="M-poneratoxin-Dq3c"
FT /evidence="ECO:0000305|PubMed:28976889"
FT /id="PRO_0000451100"
SQ SEQUENCE 66 AA; 7079 MW; FC67DC9666F845C8 CRC64;
MKLSALSIIF GMILVMTIMY TKAEAEAEAE ADADADAKAE AEAFWGTLAK WALKAIPAAM
GMKQNK
